In 1999, the CDC published an implementation guide for messaging immunization histories. Two value sets were defined that allowed specification of the vaccine used at the vaccine administration level. The CVX code is a numeric string, which identifies the type of vaccine product used. The MVX code is an alphabetic string that identifies the manufacturer of that vaccine. Taken together, the immunization can be resolved to a trade name (the proprietary name of the product).

For example, a CVX code of 43 represents Hepatitis B, adult formulation. There are 2 manufacturers of this vaccine, GlaxoSmithKline (MVX = SKB) and Merck (MVX = MSD). An immunization using Recombivax, a Hepatitis B vaccine manufactured by Merck, would have a CVX of 43 and an MVX of MSD.

When these codes were developed, they were designed to accommodate reporting of vaccine histories when the manufacturer and trade name are not known. This is because a client often had a shot card listing the vaccinations received, but with only a date and vaccine group listed. If the manufacturer and formulation were not known, then the Hepatitis B vaccine administered would be coded with a CVX of 45 (Hepatitis B, not otherwise specified).

Other codes exist that are associated with the coding of a vaccine. These include: RxNorm, NDC, and CPT®. RxNorm, a standardized nomenclature for clinical drugs and drug delivery devices, is produced by the National Library of Medicine (NLM). In RxNorm, the name of a clinical drug combines its ingredients, strengths, and/or form.

Typically, there are a number of factors that determine which vaccine will have the same or a different CVX code:

• the formulation
• the concentration
• the manufacturing process (egg culture vs. cell culture)
• the route of administration

The CDC's National Center of Immunization and Respiratory Diseases (NCIRD) developed and maintains the CVX (vaccine administered) code set. CVX codes for inactive vaccines allow transmission of historical immunization records. When a MVX (manufacturer) code is paired with a CVX (vaccine administered) code, the specific trade named vaccine may be indicated.

Use ICD-10-CM code Z23  Encounter for immunization to.  CPT® codes are specific to the type of vaccine.

MVX Codes - Manufacturers of Vaccines

The MVX is an alphabetic string, which represents the manufacturer of a vaccine. When MVX code is paired with a CVX (vaccine administered) code, the specific trade named vaccine may be indicated. The MVX code reflects the manufacturer of the specific instance of the vaccine. For example, Pfizer (MVX = PFR) acquired Wyeth (MVX = WAL). Prevnar is a vaccine that was manufactured by Wyeth. Immunizations of Prevnar that were manufactured by Wyeth continue to use the MVX of WAL. Prevnar that is now manufactured by Pfizer will have an MVX of PFR. Existing records will not be changed.

source: https://www.cdc.gov/vaccines/programs/iis/downloads/business-rules.pdf

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