Plasma cell neoplasms

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2025-01


Plasma cell neoplasms are a group of disorders characterized by the monoclonal expansion of terminally differentiated B cells (plasma cells) that produce monoclonal immunoglobulins, known as M proteins or paraproteins. Key types include plasma cell myeloma (multiple myeloma), plasmacytoma, and neoplasms associated with paraneoplastic syndromes like POEMS syndrome.

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