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Malignant neoplasms of liver or intrahepatic bile ducts

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

The most frequent and important hepatic neoplasm is the primary hepatocellular carcinoma (HCC). In many parts of the world, in particular Africa and Asia, it poses a significant disease burden. In these high incidence regions, chronic infection with hepatitis B virus (HBV) is the principal underlying cause, with the exception of Japan which has a high prevalence of hepatitis C infection. HBV vaccination has become a powerful tool in reducing cirrhosis and HCC, but implementation is still suboptimal in several high risk regions. In Western countries, chronic alcohol abuse is a major aetiological factor. Hepatic cholangiocarcinoma has a different geographical distribution, with peak incidences in Northern Thailand. Here, it is caused by chronic infection with the liver fluke, Opisthorchis viverrini, which is ingested through infected raw fish.

exclusions

• Secondary malignant neoplasm of liver  (2D80)
• Malignant neoplasm of biliary tract NOS  (2C17)

sections/codes in this section (2C12-2C12)

• Malignant neoplasm of liver  (2C12.0)
• Malignant neoplasm of intrahepatic bile ducts  (2C12.1)

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