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Myeloid proliferation associated with Down syndrome

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Myeloid neoplasms occurring in individuals with Down syndrome. There is an increased risk of acute leukaemias in both children and adults with Down syndrome. In particular, the incidence of acute myeloid leukaemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukaemia, and is associated with GATA1 gene mutation. This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.

sections/codes in this section (2A60.4-2A60.4)

• Transient abnormal myelopoiesis  (2A60.40)
• Myeloid leukaemia associated with Down syndrome  (2A60.41)
• Other specified myeloid proliferation associated with Down syndrome  (2A60.4Y)
• Myeloid proliferation associated with Down syndrome, unspecified  (2A60.4Z)

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