Classical Hodgkin lymphoma

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Classical Hodgkin lymphoma is a B-cell lymphoma characterised histologically by the presence of large mononuclear Hodgkin cells and multinucleated Reed-Sternberg (HRS) cells. A monoclonal B-cell lymphoproliferation in the vast majority of cases. It is characterised by a bimodal age distribution (15-30 years of life and late life) and is often associated with EBV infection. In less than 5% of cases it is a monoclonal proliferation of T-lymphocytes. Morphologically, it is characterised by the presence of Reed-Sternberg cells and mononuclear Hodgkin cells. The Reed-Sternberg and mononuclear Hodgkin cells are CD30 positive in nearly all cases and CD15 positive in the majority of cases.

sections/codes in this section (2B30.1-2B30.1)

• Nodular sclerosis classical Hodgkin lymphoma  (2B30.10)
• Lymphocyte-rich classical Hodgkin lymphoma  (2B30.11)
• Mixed cellularity classical Hodgkin lymphoma  (2B30.12)
• Lymphocyte depleted classical Hodgkin lymphoma  (2B30.13)
• Classical Hodgkin lymphoma, unspecified  (2B30.1Z)

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