Coding experts Alicia and Laureen from CCO review the new 2025 ICD-10-CM code changes.
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5D00.2 Hereditary amyloidosis International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01 Hereditary amyloidosis (familial amyloidosis) is an inherited disorder that often affects the liver, nerves, heart and kidneys. Many different types of gene abnormalities present at birth are associated with an increased risk of amyloid disease. The type and location of an amyloid gene abnormality can affect the risk of certain complications, the age at which symptoms first appear, and the way the disease progresses over time.
sections/codes in this section (5D00.2-5D00.2) postcoordination Add Stem and/or Extension codes to form a cluster code which adds detail to the condition.
Specific anatomy - multiple selections are allowed [select] XA9738 Brain – XA1M33 Cerebrum –– XA8GR3 Cerebral hemisphere ––– XA2NT0 Frontal Lobe –––– XA3RD9 Frontal pole ––– XA97T4 Temporal lobe –––– XA7BD1 Hippocampus –––– XA7J78 Uncus –––– XA1XY9 Amygdala ––– XA92Y6 Parietal Lobe ––– XA89Y2 Occipital lobe –––– XA5TY2 Brodmann area –––– XA0B59 Occipital pole –– XA64R0 Cerebral cortex –– XA7L93 Thalamus –– XA4T82 Basal ganglia ––– XA64F9 Corpus striatum –––– XA8W72 Lentiform nucleus ––––– XA80J3 Globus pallidus ––––– XA8KA5 Putamen –––– XA7TX5 Caudate nucleus ––– XA00D6 Claustrum –– XA5TX3 Optic chiasm –– XA63Y1 Optic tract –– XA5CF8 Visual cortex –– XA1ZN9 Cerebral white matter –– XA0XP7 Insula –– XA5JN6 Internal capsule –– XA84G1 Operculum –– XA4F88 Pallium –– XA0Z39 Rhinencephalon –– XA5N14 Cerebral lobe –– XA73A8 Supratentorial region of brain – XA1CW2 Cerebellum –– XA4SL2 Cerebellar hemisphere –– XA7E38 Cerebellar tonsil –– XA8E64 Cerebellar vermis ––– XA5694 Superior vermis ––– XA70Y8 Inferior vermis – XA8733 Limbic system – XA26E8 Cerebral ventricle –– XA45Y8 Lateral ventricle of the brain ––– XA1XM1 Choroid plexus of lateral ventricle –– XA1H64 Third ventricle of the brain ––– XA53A3 Choroid plexus of third ventricle –– XA83T2 Cerebral aqueduct –– XA1804 Fourth ventricle of the brain ––– XA1B86 Choroid plexus of fourth ventricle –– XA9KX2 Choroid plexus –– XA6J38 Ependyma – XA8AT9 Brainstem –– XA17J6 Medulla oblongata –– XA5KS6 Midbrain ––– XA1AA8 Cerebral peduncle –– XA9CM4 Pons –– XA34M4 Reticular formation –– XA5KN2 Olives –– XA5097 Pyramid –– XA1GA1 Infratentorial region of brain – XA08F7 Intracranial site, not elsewhere classified ––– XA7NQ7 Left anterior descending coronary artery –––– XA2N78 Diagonal branches of left anterior descending coronary artery ––––– XA20E5 D1 - first diagonal branch ––––– XA86J1 D2 - second diagonal branch ––––– XA5SR3 D3 - third diagonal branch ––– XA1SH6 Left obtuse marginal artery ––– XA3QP2 Ramus intermedius artery ––– XA5LW8 Septal artery –– XA2QX7 Right coronary artery ––– XA1LL7 Right acute marginal artery ––– XA81T7 Posterior interventricular artery ––– XA8PS0 Posterolateral artery ––– XA7TB5 Sinoatrial nodal artery – XA9FK9 Cardiac veins –– XA6YW4 Oblique vein of the left atrium –– XA0HP7 Left marginal vein of heart –– XA38Z5 Great cardiac vein –– XA8HT6 Posterior vein of the left ventricle –– XA3UN3 Middle cardiac vein –– XA6QD7 Small cardiac vein –– XA16E4 Coronary sinus –– XA4TZ2 Anterior cardiac veins –– XA9498 Smallest cardiac vein –– XA2KE8 Right marginal vein of heart –– XA4366 Pericardial vein – XA10E0 Chamber of the heart –– XA91S4 Cardiac atrium –– XA7XU8 Cardiac ventricle – XA3113 Connective and other soft tissue of heart –– XA42G7 Arteries of heart ––– XA9X98 Pericardiophrenic artery –– XA2XU0 Pericardium ––– XA8RK9 Parietal pericardium ––– XA48H9 Pericardial cavity ––– XA37Q8 Epicardium –– XA3227 Endocardium –– XA81Z5 Cardiac septum –– XA2DC8 Papillary muscle – XA6CK2 Heart wall –– XA7RE3 Anterior wall of heart –– XA5W05 Anterolateral wall of heart –– XA2RT9 Anteroseptal wall of heart –– XA4U99 Anteroapical wall of heart –– XA3RM8 Inferior wall of heart –– XA61Y9 Inferolateral wall of heart –– XA2H88 Inferoposterior wall of heart –– XA8ZQ8 Apical-lateral wall of heart –– XA6GR4 Basal-lateral wall of heart –– XA1HH6 High lateral wall of heart –– XA3XS7 Lateral wall of heart –– XA01U7 True posterior wall of heart –– XA7D76 Posterobasal wall of heart –– XA4RC1 Posterolateral wall of heart –– XA60V2 Posteroseptal wall of heart –– XA83Q5 Septal wall of heart – XA79Z5 Cardiac electrical conducting system –– XA1UE3 Sinoatrial node –– XA4359 Atrioventricular node –– XA7J11 Bundle of His – XA0QB6 Heart valve – XA8SK6 Myocardium XA6H07 Heart – XA6548 Left atrium –– XA7V72 Mitral valve ––– XA3GE9 Cusps of mitral valve ––– XA69W6 Chordae tendineae of mitral valve – XA78X5 Interatrial septum – XA6T92 Right atrium –– XA6FF2 Tricuspid valve ––– XA19H9 Cusps of tricuspid valve ––– XA4LY3 Chordae tendineae of tricuspid valve – XA8FJ7 Left ventricle –– XA19J4 Aortic valve ––– XA2QK7 Cusps of aortic valve –– XA7S34 Left ventricular papillary muscles – XA5651 Interventricular septum – XA9HH8 Right ventricle –– XA5Y16 Right ventricular papillary muscles –– XA6WC4 Pulmonary valve ––– XA1403 Cusps of pulmonary valve – XA3B03 Coronary arteries –– XA0F62 Left main coronary artery ––– XA9FX9 Left circumflex artery XA57M6 Lung – XA9TC5 Main bronchus –– XA3L52 Right main bronchus –– XA5FV2 Left main bronchus – XA4JA0 Carina – XA7EZ3 Right lung –– XA29Y4 Hilum of right lung –– XA8Z30 Right upper lobe bronchus –– XA41Z3 Right lower lobe bronchus –– XA1QM3 Right middle lobe bronchus – XA2UD3 Left lung –– XA6VA2 Hilum of left lung –– XA6F58 Left upper lobe bronchus ––– XA4565 Lingula of lung –– XA2XH5 Left lower lobe bronchus – XA90M2 Lobe of lung –– XA9HN5 Upper lobe of lung –– XA1N36 Middle lobe of lung –– XA7L34 Lower lobe of lung –– XA37W0 Upper lobe, bronchus –– XA1K94 Middle lobe, bronchus –– XA8JM5 Lower lobe, bronchus – XA2PV7 Connective and other soft tissues of lung –– XA61M6 Bronchus –– XA8Z62 Lung parenchyma ––– XA5437 Bronchioles ––– XA5772 Alveoli –– XA4646 Pulmonary vasculature ––– XA8FY4 Pulmonary vein –––– XA1WN5 Left pulmonary vein ––––– XA9941 Left superior pulmonary vein ––––– XA8TW3 Left inferior pulmonary vein –––– XA86L0 Right pulmonary vein ––––– XA05T2 Right superior pulmonary vein ––––– XA41F3 Right inferior pulmonary vein ––––– XA4530 Accesory right pulmonary vein –––– XA1SF4 Common left sided trunk of pulmonary veins ––– XA0F36 Pulmonary capillaries –– XA5TT2 Pleura ––– XA1B59 Visceral pleura ––– XA7RC6 Parietal pleura – XA4U64 Artery of lung –– XA2AT1 Efferent arteriole of the interlobular artery –– XA6WT9 Interlobar artery –– XA2S57 Interlobular artery –– XA3713 Pulmonary trunk XA6KU8 Kidney – XA5EP6 Renal capsule – XA35W4 Renal cortex – XA91E4 Renal medulla –– XA9Q52 Renal pyramid – XA21J4 Renal pelvis –– XA0AC1 Renal calyces ––– XA6N83 Major calyx ––– XA8XL0 Minor calyx –– XA7NQ9 Ureteropelvic junction – XA4UD2 Renal hilum – XA40R2 Glomerulus –– XA8AN8 Nephron –– XA2364 Renal tubule ––– XA15W6 Lower lip –– XA9Y82 Lateral border of foot –––– XA5VD0 External lower lip –– XA3WM8 Medial border of foot –––– XA9TK2 Vermilion border of lower lip –– XA3T29 Arch of foot –––– XA7H02 Vermilion of lower lip – XA4LC9 Toes ––– XA1BP2 Inner aspect of lip –– XA2RP7 Great toe –––– XA3141 Frenulum of lip ––– XA4774 Perionychium of great toe ––– XA3K27 External lip –––– XA8L19 Proximal nail fold of great toe –– XA2C62 Chin –––– XA7WP9 Eponychium of great toe – XA04T9 Skin of nose –––– XA7GD8 Lateral nail fold of great toe XA7AA6 Neck –––– XA2F64 Hyponychium of great toe XA4QS6 Front of neck ––– XA1RE3 Great toenail – XA1NS6 Anterior triangle of neck –––– XA64R9 Lunula of great toe –– XA5TZ1 Submental region –––– XA0HX8 Nail bed of great toe –– XA0MP5 Submandibular region –––– XA47T1 Nail plate of great toe –– XA8RA2 Suprasternal notch ––– XA6VJ2 Pad of great toe – XA9DQ5 Supraclavicular region –– XA8ZZ3 Second toe XA2ZF0 Side of neck ––– XA5446 Perionychium of second toe – XA45K8 Posterior triangle of neck –––– XA1ED1 Proximal nail fold of second toe XA1M78 Nape of neck –––– XA0SL7 Eponychium of second toe XA3FR3 Trunk –––– XA7003 Lateral nail fold of second toe XA4QH7 Upper trunk –––– XA2ZJ7 Hyponychium of second toe XA5D93 Thorax ––– XA7GG3 Second toenail – XA55T2 Chest wall –––– XA9439 Lunula of second toe –– XA00R3 Anterior thoracic region –––– XA7B22 Nail bed of second toe ––– XA8ML7 Upper anterior thoracic region –––– XA1WQ6 Nail plate of second toe –––– XA4MN6 Clavicular region ––– XA3626 Pad of second toe –––– XA6M63 Infraclavicular region –– XA0SP3 Third toe –––– XA5MS8 Presternal region ––– XA3UC8 Perionychium of third toe ––– XA7GU3 Lower anterior thoracic region –––– XA2484 Proximal nail fold of third toe –– XA7884 Lateral thoracic region –––– XA8DQ2 Eponychium of third toe ––– XA9RL9 Upper lateral thoracic region –––– XA1MM3 Lateral nail fold of third toe –––– XA0XL3 Anterolateral upper thoracic region –––– XA2H72 Hyponychium of third toe –––– XA5C28 Posterolateral upper thoracic region ––– XA5JP9 Pad of third toe ––– XA9MN4 Lower lateral thoracic region ––– XA3D73 Third toenail –––– XA3266 Anterolateral lower thoracic region –––– XA9UL1 Lunula of third toe –––– XA7MS4 Posterolateral lower thoracic region –––– XA6189 Nail bed of third toe – XA10L7 Upper back –––– XA3LW9 Nail plate of third toe –– XA3PG8 Suprascapular region –– XA4KK7 Fourth toe –– XA3WD7 Scapular region ––– XA40R3 Perionychium of fourth toe –– XA9LN5 Interscapular region –––– XA2Y79 Proximal nail fold of fourth toe –– XA8NK1 Infrascapular region –––– XA0XZ8 Eponychium of fourth toe –– XA6RF2 Lower thoracic paraspinal region –––– XA0PV4 Lateral nail fold of fourth toe – XA8EK1 Skin of thorax –––– XA4ZB3 Hyponychium of fourth toe XA12C1 Breast ––– XA9316 Pad of fourth toe – XA1NS5 Upper half of breast ––– XA6TS5 Fourth toenail –– XA3LS6 Upper inner quadrant of breast –––– XA2PD3 Lunula of fourth toe –– XA2Q54 Upper outer quadrant of breast –––– XA65U3 Nail bed of fourth toe –– XA3PG5 Axillary tail of breast –––– XA8F87 Nail plate of fourth toe – XA0US1 Central portion of breast –– XA42W4 Fifth toe –– XA2JK3 Areola ––– XA1AV3 Perionychium of fifth toe –– XA85A1 Lactiferous ducts –––– XA43K6 Proximal nail fold of fifth toe –– XA5MC5 Nipple –––– XA2W24 Eponychium of fifth toe – XA3UY3 Lower half of breast –––– XA38J0 Lateral nail fold of fifth toe –– XA0VX8 Lower inner quadrant of breast –––– XA0DD8 Hyponychium of fifth toe –– XA94U2 Lower outer quadrant of breast ––– XA3C43 Pad of fifth toe – XA9CM2 Lateral half of breast ––– XA3VM6 Fifth toenail – XA3JH6 Medial half of breast –––– XA1PK7 Lunula of fifth toe – XA0T50 Inframammary flexure –––– XA9L52 Nail bed of fifth toe XA6CY1 Lower trunk –––– XA4U10 Nail plate of fifth toe XA6GV0 Abdomen –– XA9LJ5 Plantar surface of toe – XA0U66 Upper abdomen –– XA7J49 Dorsal surface of toe –– XA8ZL8 Epigastrium –– XA14Y9 Side of toe –– XA3TD4 Hypochondrium –– XA9E36 Toenail – XA1LM1 Periumbilical region –– XA3MT8 Umbilicus – XA1DN2 Lateral lumbar region – XA4TC0 Lower abdomen –– XA6N20 Hypogastrium –– XA0NH8 Iliac region – XA3KX0 Abdominal wall –– XA4SN6 Anterior abdominal wall XA25R8 Lumbosacral region – XA6ZR2 Mid back –– XA7ZW8 Lumbar paraspinal region –– XA8FK6 Posterior lumbar region – XA9ET2 Lower back –– XA6DS1 Coccygeal area –– XA2UC8 Sacral region ––– XA4L23 Sacrococcygeal region XA2P90 Back XA8HA7 Anogenital region XA5FG3 Genital region – XA9PG6 Female external genitalia – XA1AK8 Male external genitalia –– XA8MT4 Scrotum XA9PX3 Perigenital region – XA0LF4 Suprapubic area – XA10Z0 Mons pubis – XA2XG2 Inguinocrural fold –– XA00B4 Inguinal canal XA4B34 Perianal region – XA53N9 Perineum – XA2F27 Intergluteal cleft XA6AS2 Extremities XA4BA8 Upper extremity XA2ND5 Shoulder – XA3PZ3 Anterior surface of shoulder – XA5BU5 Apex of shoulder – XA34G7 Posterior surface of shoulder XA17J1 Axilla – XA41A1 Anterior axillary fold – XA86E8 Apex of axilla – XA2RY5 Posterior axillary fold XA6809 Upper arm – XA22Q1 Anterior surface of upper arm – XA2W33 Lateral surface of upper arm – XA5TK8 Posterior surface of upper arm – XA3J41 Medial surface of upper arm XA9FF8 Elbow – XA9NE6 Antecubital fossa – XA6599 Lateral condylar surface of elbow – XA3RT8 Elbow tip – XA4983 Medial condylar surface of elbow XA7WB0 Forearm – XA8ZL6 Volar surface of forearm – XA1VA2 Lateral surface of forearm – XA8WH0 Dorsal surface of forearm – XA2Q46 Medial surface of forearm XA2J63 Wrist – XA6AR5 Volar surface of wrist – XA3LK1 Radial border of wrist – XA0SH5 Dorsal surface of wrist – XA0J47 Ulnar border of wrist XA5R12 Hand – XA30Z6 Dorsum of hand –– XA3T43 Knuckles – XA65Z3 Interdigital web space of hand –– XA1BR6 First interdigital web space of hand –– XA5PY9 Second interdigital web space of hand –– XA4012 Third interdigital web space of hand –– XA3WG2 Fourth interdigital web space of hand – XA3NY8 Palm of hand –– XA3FJ0 Proximal palm ––– XA2JN4 Thenar eminence ––– XA5TQ4 Hypothenar eminence –– XA50E4 Central palm –– XA00D7 Distal palm – XA2593 Fingers and thumb –– XA8DJ6 Thumb ––– XA0RL8 Perionychium of thumb –––– XA13E9 Proximal nailfold of thumb –––– XA20L7 Eponychium of thumb –––– XA4GD7 Lateral nailfold of thumb –––– XA63L0 Hyponychium of thumb ––– XA5PD5 Thumbnail –––– XA6DM1 Lunula of thumb –––– XA9N39 Nail bed of thumb –––– XA5V24 Nail plate of thumb ––– XA5ZV0 Pad of thumb ––– XA76N2 Dorsum of thumb –– XA6NZ0 Index finger ––– XA6YH1 Perionychium of index finger –––– XA90K8 Eponychium of index finger –––– XA2UG0 Hyponychium of index finger ––– XA40D9 Index fingernail –––– XA1GS3 Lunula of index finger –––– XA1SB3 Nail bed of index finger –––– XA2XE0 Nail plate of index finger ––– XA6TA9 Pad of index finger –– XA0Y38 Middle finger ––– XA1FY2 Perionychium of middle finger –––– XA8YE5 Proximal nail fold of middle finger –––– XA13L6 Eponychium of middle finger –––– XA2N38 Lateral nail fold of middle finger –––– XA8KX8 Hyponychium of middle finger ––– XA9YZ9 Middle fingernail –––– XA8VS0 Lunula of middle finger –––– XA2A53 Nail bed of middle finger –––– XA10T8 Nail plate of middle finger ––– XA79X0 Pad of middle finger –– XA06X8 Ring finger ––– XA7K11 Perionychium of ring finger –––– XA1F61 Proximal nail fold of ring finger –––– XA8L06 Eponychium of ring finger –––– XA3HG9 Lateral nail fold of ring finger –––– XA1W89 Hyponychium of ring finger ––– XA6Y59 Ring fingernail –––– XA4P58 Lunula of ring finger –––– XA3MW5 Nail bed of ring finger –––– XA3PS0 Nail plate of ring finger ––– XA6C72 Pad of ring finger –– XA5EN3 Little finger ––– XA89P0 Perionychium of little finger –––– XA4KU5 Proximal nail fold of little finger –––– XA2AV8 Eponychium of little finger –––– XA3LC5 Lateral nail fold of little finger –––– XA1C10 Hyponychium of little finger ––– XA4WN3 Pad of little finger ––– XA29K9 Little fingernail –––– XA3R66 Lunula of little finger –––– XA6HB9 Nail bed of little finger –––– XA4A79 Nail plate of little finger –– XA4HZ3 Side of finger –– XA7GT9 Tips of fingers ––– XA41X5 Tip of index finger ––– XA9Y99 Tip of middle finger ––– XA91S7 Tip of ring finger ––– XA8QW7 Tip of little finger XA1RS6 Head and neck – XA0EH9 Fingernails XA20Q1 Head XA66R9 Skin of elbow XA6CW5 Scalp XA45A6 Lower extremity – XA0WK0 Frontal scalp XA3VA7 Buttock –– XA0WG9 Frontal scalp margin – XA5UE3 Gluteal fold – XA9DZ0 Temporal scalp XA5S78 Thigh –– XA26C1 Temporal scalp margin – XA98B3 Anterior surface of thigh – XA4W34 Parietal scalp – XA8RH9 Lateral surface of thigh – XA7JE5 Occipital scalp –– XA4TQ2 Trochanteric region –– XA3EK3 Occipital scalp margin – XA0183 Posterior surface of thigh – XA5BY6 Vertex of scalp – XA1YQ6 Medial surface of thigh – XA6AL1 Scalp margin –– XA9ZB4 Upper medial surface of thigh –– XA93S9 Parietal scalp margin XA8KL5 Knee XA86S4 Face – XA9L17 Patellar region – XA6TR8 Forehead – XA77E9 Lateral surface of knee –– XA9SG2 Central forehead – XA9S09 Medial surface of knee –– XA1UW4 Paramedian forehead – XA4DM3 Popliteal fossa –– XA1Z38 Lateral forehead XA3YG1 Lower leg –– XA90D8 Glabella – XA33X4 Anterior surface of lower leg – XA9T94 Temple – XA4K86 Calf – XA29E7 Orbital region –– XA4RR4 Lateral surface of lower leg –– XA0SB3 Periorbital region –– XA0LQ2 Posterior surface of lower leg ––– XA5WP1 Supraorbital region –– XA15P0 Medial surface of lower leg –––– XA1LZ5 Eyebrow – XA5U49 Distal lower leg ––– XA6TV2 Infraorbital region – XA90X0 Proximal lower leg – XA7MK8 Cheek XA67V4 Ankle –– XA5KE9 Upper cheek – XA2V14 Anterior surface of ankle ––– XA0M67 Malar region – XA7AM4 Lateral surface of ankle –––– XA57N0 Malar eminence –– XA1D83 Lateral supramalleolar region –– XA6C41 Central cheek –– XA41K4 Lateral retromalleolar region –– XA3ZL3 Paranasal region – XA7P78 Medial surface of ankle –– XA7207 Lower cheek –– XA87M9 Medial supramalleolar region ––– XA0SU2 Preauricular region –– XA1SM7 Medial retromalleolar region ––– XA8KA2 Mandibular region – XA6AP4 Posterior surface of ankle – XA3H13 Nose XA47V8 Foot –– XA0LR7 Root of nose – XA99M7 Hindfoot –– XA5YP3 Dorsum of nose –– XA5HK0 Heel ––– XA3057 Supratip of nose ––– XA5ZE2 Posterior surface of heel –– XA9JN5 Lateral side wall of nose ––– XA1QH8 Medial surface of heel –– XA56T3 Tip of nose ––– XA3R99 Lateral surface of heel ––– XA3ZG3 Infratip lobule of nose ––– XA2N02 Plantar surface of heel –– XA32Q9 Ala nasi – XA5151 Midfoot ––– XA5ED7 Alar groove –– XA02P2 Dorsal surface of midfoot ––– XA7LG9 Alar rim – XA5YL1 Forefoot ––– XA2TK5 Side wall of ala nasi –– XA81Z3 Dorsal surface of forefoot –– XA1B05 Nostril –– XA1FL5 Interdigital web space of foot ––– XA4S17 Columella ––– XA81N1 First interdigital web space of foot ––– XA9YZ7 Sill of nostril ––– XA8HC5 Second interdigital web space of foot – XA5A87 Oral region ––– XA9LB9 Third interdigital web space of foot –– XA1A48 Perioral region ––– XA2A07 Fourth interdigital web space of foot –– XA8JD4 Lip –– XA6KE9 Plantar surface of forefoot ––– XA7VQ4 Upper lip ––– XA6V29 First metatarsal head region –––– XA0K68 External upper lip ––– XA2P22 Second metatarsal head region ––––– XA5LY8 Philtrum ––– XA0HX4 Third metatarsal head region ––––– XA5163 Nasolabial fold ––– XA86J0 Fourth metatarsal head region –––– XA8RK1 Vermilion border of upper lip ––– XA05N7 Fifth metatarsal head region –––– XA75S0 Vermilion of upper lip – XA8BE2 Dorsum of foot ––– XA1EF8 Labial commissure – XA1XM4 Sole of foot
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