8C81 Autoimmune myopathy

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2025-01

Autoimmune myopathy is a subgroup of idiopathic inflammatory myopathies, which, despite diverse causes, have the common histopathological features of myocyte necrosis without significant inflammation. Patients present with a subacute severe symmetrical proximal myopathy, associated with a markedly elevated creatine kinase level. These are most likely immune-mediated, as they respond to immunotherapy. It is often accompanied by statin therapy, connective tissue diseases, cancer, and autoantibodies specific for signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR).

exclusions

• Myasthenia gravis or certain specified neuromuscular junction disorders  (8C60-8C6Z)
• Primary disorders of muscles  (8C70-8C7Z)

postcoordination

synonyms

• Autoimmune myopathy

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