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GB90.4A Nephrogenic diabetes insipidus

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. Polyuria with dilute urine and polydypsia (excessive thirst) are present. It can be congenital or acquired with many causes. The congenital forms may be attributed to vasopressin receptor or aquaporin-2 defects. They are characterised by polyuria with polydipsia, recurrent bouts of fever, constipation, and acute hypernatraemic dehydration after birth that may cause neurological sequelae.

exclusions

• Central diabetes insipidus  (5A61.5)

synonyms

• Nephrogenic diabetes insipidus
• renal diabetes insipidus
• familial nephrogenic diabetes
• antidiuretic-hormone-resistant diabetes insipidus
• adiuretin-resistant diabetes insipidus
• NDI - [nephrogenic diabetes insipidus]
• diabetes tenuifluus
• ADH - [antidiuretic-hormone] resistant diabetes insipidus
• congenital nephrogenic diabetes insipidus
• hereditary nephrogenic diabetes insipidus
• familial nephrogenic diabetes insipidus
• primary nephrogenic diabetes insipidus
• Nephrogenic diabetes insipidus - intracranial calcification
• Nephrogenic Diabetes Insipidus associated with familial or genetic disorders elsewhere classified
• AQP2 mutation
• X-linked AVPR2 mutation
• Acquired nephrogenic diabetes insipidus due to causes classified elsewhere
• Vasopressin-resistant hyposthenuria
• vasopressin-resistant diabetes insipidus
• Vasopressin-unresponsiveness hyposthenuria

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