EB13.1 Toxic epidermal necrolysis

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Toxic epidermal necrolysis (TEN) is an acute life-threatening skin disease with commonly quoted overall risk of mortality of between 25 and 30%, though the risk of fatal outcome is around 90% in the most severely affected patients (SCORTEN score >5). It is characterised by the rapid onset of extensive erythema, necrosis, and bullous detachment of the epidermis (> 30% body surface area). Commonly, the mucous membranes are also involved. Death may result from a combination of sepsis, fluid depletion and multi-organ failure. In two thirds of cases, TEN is triggered by a clearly identifiable drug allergy.

code elsewhere

• Drug-induced toxic epidermal necrolysis  (EH63.1)

synonyms

• Toxic epidermal necrolysis
• Lyell syndrome (toxic epidermal necrolysis)
• TEN - [toxic epidermal necrolysis]
• Lyell syndrome

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