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2A60.4 Myeloid proliferation associated with Down syndrome International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01 Myeloid neoplasms occurring in individuals with Down syndrome. There is an increased risk of acute leukaemias in both children and adults with Down syndrome. In particular, the incidence of acute myeloid leukaemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukaemia, and is associated with GATA1 gene mutation. This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.
sections/codes in this section (2A60.4-2A60.4) postcoordination Add Stem and/or Extension codes to form a cluster code which adds detail to the condition.
Histopathology - only one may be selected [select] XH0E35 Chronic monocytic leukaemia XH6JX2 Eosinophilic leukaemia XH5JT8 Monocytic leukaemia, NOS XH1S60 Subacute monocytic leukaemia XH7DF6 Subacute myeloid leukaemia XH8AA5 Acute myeloid leukaemia, NOS XH4M02 Acute myeloid leukemia with biallelic mutation of CEBPA XH74W8 Acute myeloid leukaemia with mutated NPM1 XH4XG8 Chronic myeloid leukaemia, NOS XH9Y46 Acute myeloid leukaemia with t(6;9)(p23;q34); DEK-NUP214 XH1A50 Acute promyelocytic leukaemia, t(15;17)(q22;q11-12) XH78Y4 Acute myelomonocytic leukaemia XH2KE3 Acute myeloid leukaemia with inv(3)(q21;q26.2) or t(3.3)(q21;q26.2); RPN1-EVI1 XH7MR1 Acute basophilic leukaemia XH3PA4 Acute myeloid leukaemia with abnormal marrow eosinophils XH90G0 Acute myeloid leukaemia, minimal differentiation XH5AH8 Acute myeloid leukaemia without maturation XH1XJ9 Acute myeloid leukaemia with maturation XH2AB7 Chronic myelogenous leukaemia, BCR/ABL positive XH21X5 Atypical chronic myeloid leukaemia, BCR/ABL negative XH26U9 Atypical chronic myeloid leukaemia, Philadelphia chromosome (Ph1) negative XH9NE2 Acute monocytic leukaemia XH1K97 Acute monoblastic and monocytic leukaemia XH64R4 Acute myeloid leukaemia with myelodysplasia-related changes XH3CX5 Acute myeloid leukaemia, t(8;21)(q22;q22) XH1E41 Acute myeloid leukaemia, 11q23 abnormalities XH6AQ7 Myeloid leukaemia associated with Down Syndrome XH4750 Acute megakaryoblastic leukaemia XH16K4 Acute myeloid leukaemia (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1 XH7045 Therapy related myeloid neoplasm XH6Z50 Therapy-related acute myeloid leukaemia, alkylating agent related XH4EJ0 Therapy-related acute myeloid leukaemia, epipodophyllotoxin-related XH3L40 Myeloid sarcoma XH1075 Acute panmyelosis with myelofibrosis XH6FZ7 Acute myeloid leukemia with BCR-ABL1 XH1EK4 Acute myeloid leukemia with mutated RUNX1 XH43N4 Acute erythroid leukemia XH7S21 Myeloid leukaemia, NOS XH7LG8 Aleukemic myeloid leukaemia XH5DV4 Aleukemic monocytic leukaemia XH67W4 Transient abnormal myelopoiesis XH43N4 Acute erythroid leukemia XH7S21 Myeloid leukaemia, NOS XH7LG8 Aleukemic myeloid leukaemia XH5DV4 Aleukemic monocytic leukaemia XH0E35 Chronic monocytic leukaemia XH6JX2 Eosinophilic leukaemia XH5JT8 Monocytic leukaemia, NOS XH1S60 Subacute monocytic leukaemia XH7DF6 Subacute myeloid leukaemia XH8AA5 Acute myeloid leukaemia, NOS XH4M02 Acute myeloid leukemia with biallelic mutation of CEBPA XH74W8 Acute myeloid leukaemia with mutated NPM1 XH4XG8 Chronic myeloid leukaemia, NOS XH9Y46 Acute myeloid leukaemia with t(6;9)(p23;q34); DEK-NUP214 XH1A50 Acute promyelocytic leukaemia, t(15;17)(q22;q11-12) XH78Y4 Acute myelomonocytic leukaemia XH2KE3 Acute myeloid leukaemia with inv(3)(q21;q26.2) or t(3.3)(q21;q26.2); RPN1-EVI1 XH7MR1 Acute basophilic leukaemia XH3PA4 Acute myeloid leukaemia with abnormal marrow eosinophils XH90G0 Acute myeloid leukaemia, minimal differentiation XH5AH8 Acute myeloid leukaemia without maturation XH1XJ9 Acute myeloid leukaemia with maturation XH2AB7 Chronic myelogenous leukaemia, BCR/ABL positive XH21X5 Atypical chronic myeloid leukaemia, BCR/ABL negative XH26U9 Atypical chronic myeloid leukaemia, Philadelphia chromosome (Ph1) negative XH9NE2 Acute monocytic leukaemia XH1K97 Acute monoblastic and monocytic leukaemia XH64R4 Acute myeloid leukaemia with myelodysplasia-related changes XH3CX5 Acute myeloid leukaemia, t(8;21)(q22;q22) XH1E41 Acute myeloid leukaemia, 11q23 abnormalities XH67W4 Transient abnormal myelopoiesis XH6AQ7 Myeloid leukaemia associated with Down Syndrome XH4750 Acute megakaryoblastic leukaemia XH16K4 Acute myeloid leukaemia (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1 XH7045 Therapy related myeloid neoplasm XH6Z50 Therapy-related acute myeloid leukaemia, alkylating agent related XH4EJ0 Therapy-related acute myeloid leukaemia, epipodophyllotoxin-related XH3L40 Myeloid sarcoma XH1075 Acute panmyelosis with myelofibrosis XH6FZ7 Acute myeloid leukemia with BCR-ABL1 XH74W8 Acute myeloid leukaemia with mutated NPM1 XH4M02 Acute myeloid leukemia with biallelic mutation of CEBPA XH1EK4 Acute myeloid leukemia with mutated RUNX1 Has manifestation - multiple selections are allowed [select] MG30.10 Chronic cancer pain
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