2D11 Malignant neoplasms of adrenal gland

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01


Tumours arising from the adrenal cortex include adenomas and carcinomas. These are rare neoplasms but may cause a variety of hormonal symptoms, including hyperaldosteronism, Cushing syndrome, and virilisation. A small fraction of adrenocortical tumours are associated with an inherited tumour syndrome, including Li-Fraumeni syndrome and Carney complex. Benign and malignant phaeochromocytomas arise in the adrenal medulla and are derived from chromaffin cells of neural crest origin. Phaeochromocytomas may occur in the setting of several hereditary conditions, including multiple endocrine neoplasia types 2a and 2b, von Hippel Lindau disease and neurofibromatosis. Extra adrenal paragangliomas arise from chromaffin cells in sympathoadrenal and parasympathetic paraganglia. They occur in many parts of the body and can pose a significant challenge to surgeons and oncologists. Some function as chemoreceptors, others are endocrinologically active. Familial paragangliomas are associated with mutations of the mitochondrial complex II genes.

exclusions

sections/codes in this section (2D11-2D11)

postcoordination

Add Stem and/or Extension codes to form a cluster code which adds detail to the condition.

Laterality  - only one may be selected
Specific anatomy  - multiple selections are allowed
Histopathology  - only one may be selected
Has manifestation  - multiple selections are allowed
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Has alternative severity2  - only one may be selected
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