8B60.0 Amyotrophic lateral sclerosis

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder in which progressive signs of LMN and UMN degeneration are seen within one or more of the four regions: bulbar, cervical, thoracic and lumbosacral. Electrophysiological studies may be required to confirm lower motor neuron degeneration and to exclude alternative causes. Neuroimaging may be performed to exclude other causes, which might explain the clinical and electrophysiological features. Familial ALS (FALS) of autosomal dominant inheritance constitutes 5 to 10% of ALS. The clinical profile of FALS and sporadic ALS is similar. Mutations in the C9ORF72 and Cu/Zn superoxide dismutase (SOD1) genes constitute 50-60% of FALS.

postcoordination

synonyms

• Amyotrophic lateral sclerosis
• amyotrophic sclerosis
• ALS - [amyotrophic lateral sclerosis]
• wasting palsy
• amyotrophic paralysis
• amyotrophy lateral sclerosis
• wasting paralysis
• spinal progressive amyotrophy
• progressive atrophic paralysis

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