3A50.4 Hereditary persistence of fetal haemoglobin

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01


Hereditary persistence of fetal haemoglobin (HPFH) associated with beta-thalassaemia is a haemoglobinopathy characterised by high haemoglobin (Hb)F levels and an increased number of fetal-Hb-containing cells. The association of HPFH with beta-thalassaemia mitigates the clinical manifestations which vary from a normal state to beta-thalassaemia intermedia.

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