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4B24 Graft-versus-host disease International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01 Graft-versus-host disease (GVHD) occurs when lymphoid cells from an immunocompetent donor are introduced into a histo-incompatible recipient incapable of rejecting them. This usually occurs as a result of haematopoietic stem cell transplantation. The main targets attacked by the donor lymphocytes are the recipient’s skin, gastrointestinal tract and liver. Acute GVHD, normally occurring within the first 100 days following transplantation, has a high mortality. The acute phase may be followed by chronic GVHD, which can also arise de novo. This usually presents as a lichenoid rash but can develop into a severe fibrosing disease affecting skin, lungs and liver.
sections/codes in this section (4B24-4B24) postcoordination Add Stem and/or Extension codes to form a cluster code which adds detail to the condition.
Associated with - multiple selections are allowed [select] QB63 Presence of transplanted organ or tissue – QB63.0 Presence of transplanted kidney – QB63.1 Presence of transplanted heart – QB63.2 Presence of transplanted lung – QB63.3 Presence of transplanted liver – QB63.4 Presence of transplanted skin – QB63.5 Presence of transplanted bone – QB63.6 Presence of transplanted bone marrow – QB63.7 Presence of transfused blood – QB63.8 Presence of transplanted stem cell – QB63.9 Presence of transplanted cornea – QB63.Y Presence of other transplanted organ or tissue – QB63.Z Presence of transplanted organ or tissue, unspecified Has severity - only one may be selected [select] XS8H None XS5W Mild XS0T Moderate XS25 Severe XS2R Profound XS7A Stage 1 XS5S Stage 2 XS4D Stage 2a XS6D Stage 2b XS00 Stage 3 XS3T Stage 3a XS90 Stage 3b XS6G Stage 4 XS9N Stage 5 XS88 Stage 6 XS52 Stage 7 XS0G Stage 8 XS2C Stage 9 XS2X Stage 10 XS24 Grade 0 XS6P Grade 1 XS31 Grade 2 XS6F Grade 3 XS0K Grade 4 XS87 Grade 5 XS9M Grade 6 XS5M Grade 7 XS7F Grade 8 XS8J Grade 9 XS57 Grade 10 XS4A Phase 0 XS3K Phase 1 XS4M Phase 2 XS8V Phase 3 XS21 Phase 4 XS8Z Phase 5 XS41 Phase 6 XS73 Phase 7 XS9Z Phase 8 XS83 Phase 9 XS47 Phase 10 XS5C 0 No problem XS6Y 1 Mild problem XS8T 2 Moderate problem XS9D 3 Severe problem XS91 4 Complete problem XS5P 9 Not applicable XS50 GOLD 4 - very severe: FEV1 <30% predicted XS1Y Stage I: Asymptomatic, incomplete blood vessel obstruction XS5L Stage II: Mild claudication pain in limb – XS5V Stage IIA: Claudication at a distance > 200 metres – XS6C Stage IIB: Claudication at a distance < 200 metres XS9L Stage III: Rest pain, mostly in the feet XS2J Stage IV: Necrosis and/or gangrene of the limb XS3V No endometriosis XS5N Filmy endometriosis XS55 Dense endometriosis XS1H Incomplete vocal cord paralysis XS66 Partial vocal cord paralysis XS7K Complete vocal cord paralysis XS5E Mild sepsis XS65 Severe sepsis XS26 Septic shock XS1T Grade 0 Category 0: Asymptomatic -no hemodynamically significant occlusive disease XS0Q Grade 0 Category 1: Mild claudication XS2W Grade I Category 2: Moderate claudication XS51 Grade I Category 3: Severe claudication XS8M Grade II Category 4: Ischaemic rest pain XS6U Grade III Category 5: Minor tissue loss - nonhealing ulcer, focal gangrene with diffuse pedal ischaemia XS0U Grade III Category 6: Major tissue loss - extending above transmetatarsal (TM) level, functional foot no longer salvageable – XS5B No pain – XS5D Mild pain – XS9Q Moderate pain – XS2E Severe pain – XS1J No distress – XS3R Mild distress – XS7C Moderate distress – XS7N Severe distress – XS71 No pain-related interference – XS5R Mild pain-related interference – XS2L Moderate pain-related interference – XS2U Severe pain-related interference XS7G Psychosocial factors present XS8B No psychosocial factors present XS11 Underweight BMI Below 18.5 kg/m² XS43 Normal weight BMI 18.5–24.9 kg/m² XS7R Pre-obesity BMI 25.0–29.9 kg/m² XS3Y Obesity class I BMI 30.0–34.9 kg/m² XS6N Obesity class II BMI 35.0–39.9 kg/m² XS2B Obesity class III BMI greater than or equal to 40 kg/m² XS2V Single vessel disease XS8U Multiple vessel disease XS09 Anaphylaxis grade 1 XS59 Anaphylaxis grade 2 XS2Y Anaphylaxis grade 3 XS85 Anaphylaxis grade 4 XS0J A Remission / Free of disease XS05 B Local Disease – XS0E Local limited – XS67 Locally advanced XS9S C Regional disease XS4Z D Distant disease XS76 Stage 0 XS1G Stage I XS4P Stage II XS6H Stage III XS9R Stage IV XS56 Grade I XS58 Grade II XS7Z Grade III XS7M Grade IV XS7H Undetermined grade XS3A NYHA Class I - No limitation of physical activity XS6B NYHA Class II - Slight limitation of physical activity XS9T NYHA Class III - Marked limitation of physical activity XS9F NYHA Class IV - Unable to carry on any physical activity without discomfort XS80 GOLD 1 - mild: FEV1≥ 80% predicted XS7U GOLD 2 - moderate: 50% ≤FEV1 <80% predicted XS8K GOLD 3 - severe: 30% ≤FEV1 <50% predicted
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