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5A00.03 Transient congenital hypothyroidism

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Transient congenital hypothyroidism is defined as transient thyroid dysfunction with mildly elevated thyroid-stimulating hormone (TSH) and low thyroxine (FT4) levels which return to normal either very promptly and spontaneously, or after several months of thyroxine therapy. The disorder is due to a variety of causes including iodine deficiency or exposure to iodine-containing compounds, transplacental passage of blocking maternal antibodies, and dyshormonogenesis.

exclusions

• Transitory congenital goitre with normal function  (KB62)

synonyms

• Transient congenital hypothyroidism
• Transient congenital hypothyroidism due to monoallelic or biallelic mutations of dual oxidase 2 mutation
• Transient congenital hypothyroidism due to heterozygous mutations of monoallelic or biallelic mutations of DUOX2 mutation
• Transient congenital hypothyroidism due to maternal intake of antithyroid drugs
• Transient congenital hypothyroidism due to maternal iodine deficiency or excess
• Fetal iodine syndrome
• Transient congenital hypothyroidism due to neonatal iodine deficiency or excess
• Transient congenital hypothyroidism due to neonatal iodine exposure
• Transient congenital hypothyroidism due to transplacental passage of maternal TSH receptor blocking antibodies
• Transient congenital hypothyroidism due to heterozygous mutations of THOX2

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