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5C64.10 Iron overload diseases

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Iron overload is the accumulation of excess iron in body tissues. Iron overload usually occurs as a result of a genetic predisposition to absorb and store iron in excess amounts, the most common form of which is hereditary hemochromatosis. Iron overload can also occur as a complication of other hematologic disorders that require chronic transfusion therapy, repeated injections of parenteral iron, or excessive iron ingestion. Excessive iron stores usually accumulate in the reticuloendothelial tissues and cause little damage (“hemosiderosis”). If overload continues, iron eventually begins to accumulate in tissues such as hepatic parenchyma, pancreas, heart and synovium, causing hemochromatosis.

code elsewhere

• Friedreich ataxia  (8A03.10)
• Atransferrinaemia  (3A00.Y)
• Microcytic anaemia with liver iron overload  (3A00.Y)

synonyms

• Iron overload diseases
• idiopathic haemosiderosis
• hemosiderosis
• Hereditary haemochromatosis
• HFE-related hereditary haemochromatosis, Type 1
• C282Y/C282Y haemochromatosis
• Classic haemochromatosis
• Arthropathy in haemochromatosis
• Juvenile hereditary haemochromatosis, Type 2
• Juvenile hereditary haemochromatosis, Type 2A
• Hemojuvelin-related haemochromatosis
• Juvenile hereditary haemochromatosis, Type 2B
• Hepcidin-related haemochromatosis
• Non-HFE-related hereditary haemochromatosis, Type 3
• TFR2-related haemochromatosis
• Non-HFE-related hereditary haemochromatosis, Type 4
• Autosomal dominant hereditary haemochromatosis
• Haemochromatosis due to defect in ferroportin
• Ferroportin disease
• Secondary iron overload
• African iron overload
• Bantu haemosiderosis
• Iron overload in sub-Saharan Africa
• Dietary haemosiderosis
• Neurodegeneration with brain iron accumulation
• Hallervorden-Spatz disease (deprecated)
• Pigmentary pallidal degeneration
• pigmentary pallidal atrophy
• pigmentary; degeneration, pallidal (progressive)
• NBIA - [Neurodegeneration with brain iron accumulation]
• Infantile neuroaxonal dystrophy
• Seitelberger disease
• INAD - [Infantile neuroaxonal dystrophy]
• Neurodegeneration with brain iron accumulation due to C19orf12 mutation
• Pantothenate-kinase-associated neurodegeneration
• Neurodegeneration with brain iron accumulation type 1
• NBIA1 - [Neurodegeneration with brain iron accumulation type 1]
• PKAN - [Pantothenate-kinase-associated neurodegeneration]
• HARP - [hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration]
• HSS - [Hallervorden-Spatz-Syndrome] (deprecated)
• Atypical pantothenate kinase associated neurodegeneration
• Neurodegeneration with brain iron accumulation type 1, atypical form
• NBIA1 - [Neurodegeneration with brain iron accumulation type 1] atypical form
• PKAN - [Pantothenate-kinase-associated neurodegeneration] atypical form
• Classic pantothenate kinase associated neurodegeneration
• Neurodegeneration with brain iron accumulation type 1, classic form
• NBIA1 - [Neurodegeneration with brain iron accumulation type 1] classic form
• PKAN - [Pantothenate-kinase-associated neurodegeneration] classic form
• Acquired hemochromatosis
• Acquired iron overload
• Neonatal haemochromatosis

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