ICD-11 MMS

05 Endocrine, nutritional or metabolic diseases

Metabolic disorders  (5C50-5D2Z)

Disorders of metabolite absorption or transport  (5C60-5C6Z)

5C64 Disorders of mineral absorption or transport

5C64.1 Disorders of iron metabolism

5C64.10 Iron overload diseases

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01


Iron overload is the accumulation of excess iron in body tissues. Iron overload usually occurs as a result of a genetic predisposition to absorb and store iron in excess amounts, the most common form of which is hereditary hemochromatosis. Iron overload can also occur as a complication of other hematologic disorders that require chronic transfusion therapy, repeated injections of parenteral iron, or excessive iron ingestion. Excessive iron stores usually accumulate in the reticuloendothelial tissues and cause little damage (“hemosiderosis”). If overload continues, iron eventually begins to accumulate in tissues such as hepatic parenchyma, pancreas, heart and synovium, causing hemochromatosis.

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