5A60.0 Acromegaly or pituitary gigantism

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and characterised by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. The main clinical features are broadened extremities (hands and feet), widened thickened and stubby fingers, and thickened soft tissue. The disease also has rheumatologic, cardiovascular, respiratory and metabolic consequences which determine its prognosis. In the majority of cases, acromegaly is related to a pituitary adenoma, either purely GH-secreting (60%) or mixed. Transsphenoidal surgery is often the first-line treatment. When surgery fails to correct GH/IGF-I hypersecretion, medical treatment with somatostatin analogs and/or radiotherapy can be used.

inclusions

• Overproduction of growth hormone

exclusions

• constitutional gigantism  (5B12)
• increased secretion from endocrine pancreas of growth hormone-releasing hormone  (5A40-5A4Z)
• Constitutional tall stature  (5B12)

postcoordination

synonyms

• Acromegaly or pituitary gigantism
• disorders with tall stature
• genetic giant
• giant
• primordial giant
• pituitary gigantism
• Overproduction of growth hormone
• normal giant
• Launois syndrome
• Marie disease
• acromegaly
• acromegalia
• acromegalic gigantism
• anterior pituitary adenoma syndrome
• giantism
• gigantism
• growth hormone hypersecretion
• growth hormone hypersecretion syndrome
• hypersomatotropic gigantism
• hypersomatotropism
• hypophyseal gigantism
• Cardiomyopathy associated with acromegaly
• Somatotroph adenoma
• Arthropathy associated with acromegaly
• acromegaly with arthropathy
• acromegalic arthritis
• acromegalic arthropathy

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