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2B6A.0 Squamous cell carcinoma of oropharynx

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

A squamous cell carcinoma arising from the oropharynx. It predominantly affects adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterised by a tendency to metastasize early to the lymph nodes. When the tumour is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with locally advanced disease. Signs and symptoms include mucosal ulceration, pain, bleeding, weight loss, neck swelling, and difficulty speaking, chewing, and swallowing. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumour. The most significant prognostic factors are the size of the tumour and the lymph nodes status.

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synonyms

• Squamous cell carcinoma of oropharynx
• Squamous cell carcinoma of oropharynx NOS
• Lymphoepithelial carcinoma of oropharynx
• Verrucous carcinoma of oropharynx
• Spindle cell squamous cell carcinoma of oropharynx
• Papillary squamous cell carcinoma of oropharynx
• Basaloid carcinoma of oropharynx
• Adenosquamous carcinoma of oropharynx
• Basaloid squamous cell carcinoma of oropharynx
• Undifferentiated carcinoma of oropharynx
• Squamous cell carcinoma of vallecula
• Squamous cell carcinoma of anterior surface of epiglottis
• Squamous cell carcinoma of lateral wall of oropharynx
• Squamous cell carcinoma of posterior wall of oropharynx
• Squamous cell carcinoma of branchial cleft
• Squamous cell carcinoma involving overlapping sites of oropharynx

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