BCR-ABL1 p210 Major Molecular Response (MMR) [Presence] in Blood or Tissue by Molecular genetics method --post treatment   74041-5

LOINC Code


LOINC code74041-5
nameBCR-ABL1 p210 Major Molecular Response (MMR) [Presence] in Blood or Tissue by Molecular genetics method --post treatment
descriptionPatient's with CML and undergoing tyrosine kinase inhibitor (TKI) therapy may be monitored to assess their treatment response (reduction in BCR-ABL1 transcripts) to therapy. A major molecular response (MMR) occurs when the ratio of BCR-ABL1 transcripts to control gene is less than or equal to 0.1% according to the International Scale (IS), a consensus standardized measurement scale intended to allow direct comparison of BCR-ABL1 major breakpoint (b2a2, b3a2) RNA levels in any laboratory adopting its use. Studies have demonstrated that achieving MMR within 18 months following TKI therapy is associated with a minimal risk of progression at 84 months (NCCN Guidelines CML, 2013).
statusACTIVE

Fully-Specified Name

componentt(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript.reduction to 0.1%^post treatment
propertyPrThr  =  Present or threshold:  The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold.
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemBld/Tiss
    Bld  =  Whole blood
    Tiss  =  Tissue, unspecified
scaleOrd  =  Ordinal:  Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive.
methodMolgen  =  Molecular Genetics:  General class of methods used to detect genetic attributes on a molecular basis including RFL, PCR and other methods.

Additional Names

short namet(ABL1,BCR)p210/cntrl.0.1% p Tx Bld/T Ql

Basic Attributes

classMOLPATH
type1  Laboratory
order vs. observationBoth

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

History/Usage

first released
last updated2.56
last change typeMIN  - change to field other than name
change reasonThe PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Related Names

ABL
After
ALL
bcr/abl
BCR1
bcr-abl1
Blood
Breakpoint cluster region
Chronic myeloid leukemia
CML
D22S11
D22S662
DNA
e13a2
e14a2
gene fusion
gene translocation
Genetics
Hematology
Heme
Heredity
Heritable
Inherited
JTK7
major breakpoints
Mbr
Mcr
minor breakpoints
Molecular genetics
Molecular pathology
MOLPATH
Ordinal
p Tx
p150
p210
PCR
Ph chromosome
Philadelphia chromosome
PHL
Point in time
PR
PST
QL
Qual
Qualitative
Random
RNA
Screen
T prime
t(9,22)(ABL1,BCR) gene translocation
t(9,22)(ABL1,BCR) p210 gene translocation
t(9,22)(ABL1,BCR) Translocation
t(9,22)(q34,q11)
t(9,22)(q34.1,q11)
t(9
22)(ABL1,BCR)
t(ABL1,BCR)b2a2
t(ABL1,BCR)p210
Tissue
Tissue, unspecified
translocation
Tx
v-abl Abelson murine leukemia viral oncogene homolog 1
WB
Whole blood
Whole blood or Tissue

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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