82367-4
LOINC Code
| LOINC code | 82367-4 | |
|---|---|---|
| name | ||
| description | The sum activity of peripheral deiodinases (GD, also referred to as deiodination capacity or total deiodinase activity) is the maximum amount of triiodothyronine (T3) produced per time-unit by deiodinases outside the central nervous system. The structure parameter inference approach (SPINA) uses Michaelis-Menten functions and pharmakokinetic data to estimate GD under conditions of substrate saturation. One calculation is based on peripheral free T3 and free T4 values, and an alternate calculation uses peripheral total T3 and free T4. GD calculated using the SPINA approach is also known as SPINA-GD. SPINA-GD may be useful in diagnosing thyroid conditions that are difficult to diagnose based on traditional thyroid function studies, such as subclinical forms of thyroid failure, hypothalamic or pituitary dysfunction, and non-thyroidal illness syndrome. [PMID: 27375554] Thyroid secretory function by SPINA, called SPINA-GT, is a related result [LOINC: 82368-2]. | |
| status | ACTIVE | |
Fully-Specified Name | ||
| component | Peripheral deiodinase activity | |
| property | SRat = Substance Rate | |
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | |
| system | Ser/Plas Ser = Serum Plas = Plasma | |
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | |
| method | Calculated.SPINA | |
Additional Names | ||
| short name | Activ; Actvty; Calc; Calc SPINA; Calculation; Chemistry; Deiodination capacity; Movements; Per deiod act; Periph; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SPINA-GD; SR; sRate; S | |
Basic Attributes | ||
| class | CHEM | |
| type | 1 Laboratory | |
| order vs. observation | Per deiod act S | |
| formula (readable) | GD = beta31 * (KM1 + [FT4]) * (1 + K30 * [TBG]) * [FT3] / (alpha31 * [FT4]) or GD = beta31 * (KM1 + [FT4]) * [TT3] / (alpha31 * [FT4]) Please see [PMID: 27375554] for more information for the formula constants, alpha31, beta31, KM1, and K30. | |
| example UCUM units | nmol/s The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | |
History/Usage | ||
| first released | ||
| last updated | 2.58 | |
| last change type | ADD - added | |
| change reason | nmol/s | |
Related Names | ||
Copyright © 2026 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2026, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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