Natural killer cell cytotoxicity panel - Blood mononuclear cells   82720-4

LOINC Code


LOINC code82720-4
nameNatural killer cell cytotoxicity panel - Blood mononuclear cells
descriptionThe natural killer (NK) cytotoxicity profile assesses the functionality of natural killer cells and is used to evaluate patients with various conditions, including recurrent herpes viral infections, hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects. The NK cytotoxicity profile is also used for the evaluation of immune reconstitution post hematopoietic cell transplantation and post immunomodulatory therapy. Peripheral blood mononuclear cells (PBMCs) are used as the specimen for NK cytotoxicity assays because the cytotoxicity of the MC population is predominantly due to NK cells. In the cytotoxicity assay, samples of the patient's mononuclear cells (called 'effector cells' or E cells') are incubated with labeled target cells ('T cells') in a series of predetermined ratios, for example, 100:1 E to T, 50:1 E to T, 25:1 E to T. Cytotoxicity is measured as the amount of label released when the target cell is destroyed, and the percent cytotoxicity for a given E:T ratio is the ratio of label released when all of the target cells are destroyed using a cell lysis detergent as an experimental control. Several features of the cytotoxicity profile are important, including the maximum cytotoxicity, the relative difference between the maximum and the minimum, and the change in percent cytotoxicity between sequential dilutions. Different patterns of these measures may be associated with different disease processes. Cytotoxicity may also be reported in terms of lytic units [LOINC: 34439-0], meaning the number of E cells needed to lyse a certain number of target cells.
statusACTIVE

Fully-Specified Name

componentNatural killer cell cytotoxicity panel
property-
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemBld MC
    Bld  =  Whole blood
scale-
method

Additional Names

short nameNK cytotox Pnl Bld MC

Basic Attributes

classPANEL.HEM/BC
type1  Laboratory
order vs. observationOrder

Panel Components

88511-1Natural killer cell cytotoxicity.0.9:1 effector to target cell ratio/Positive control in Blood mononuclear cells
88514-5Natural killer cell cytotoxicity.1.88:1 effector to target cell ratio/Positive control in Blood mononuclear cells
82724-6Natural killer cell cytotoxicity.3.13:1 effector to target cell ratio/Positive control in Blood mononuclear cells
88515-2Natural killer cell cytotoxicity.3.75:1 effector to target cell ratio/Positive control in Blood mononuclear cells
82725-3Natural killer cell cytotoxicity.6.25:1 effector to target cell ratio/Positive control in Blood mononuclear cells
88513-7Natural killer cell cytotoxicity.7.5:1 effector to target cell ratio/Positive control in Blood mononuclear cells
82726-1Natural killer cell cytotoxicity.12.5:1 effector to target cell ratio/Positive control in Blood mononuclear cells
88512-9Natural killer cell cytotoxicity.15:1 effector to target cell ratio/Positive control in Blood mononuclear cells
82727-9Natural killer cell cytotoxicity.25:1 effector to target cell ratio/Positive control in Blood mononuclear cells
88510-3Natural killer cell cytotoxicity.30:1 effector to target cell ratio/Positive control in Blood mononuclear cells
82728-7Natural killer cell cytotoxicity.50:1 effector to target cell ratio/Positive control in Blood mononuclear cells
82729-5Natural killer cell cytotoxicity.100:1 effector to target cell ratio/Positive control in Blood mononuclear cells

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

History/Usage

first released
last updated2.64
last change typeMIN  - change to field other than name

Related Names

Blood
HEMATOLOGY/CELL COUNTS
NK
NK cytotox Pnl
Pan
PANEL.HEMATOLOGY& CELL COUNTS
Panl
PBMC
Peripheral blood mononuclear cells
Pnl
Point in time
Random
WB
Whole blood

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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