Coding updates for COVID-19 treatments

New HCPCS code for convalescent plasma for COVID-19 in the outpatient setting On December 28, 2021, the Food and Drug Administration (FDA) revised the emergency use authorization (EUA) for COVID-19 convalescent plasma with high titers of anti-SARS-CoV-2 antibodies. The revised EUA authorizes treatment of COVID-19 in patients with immunosuppressive disease or getting immunosuppressive treatment, in the outpatient or inpatient setting.  The new HCPCS code, C9507 , Fresh frozen plasma, high titer COVID-19 convalescent, frozen within 8 hours of collection, each unit, is effective on or after December 28, 2021, for convalescent plasma for use in the outpatient setting. Transfusion...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article reviews selected COVID-19 treatment coding updates tied to FDA emergency use authorization changes and CMS code creation. It is aimed at coders, billers, reimbursement staff, and compliance teams who need to track outpatient treatment coding changes, effective dates, and related HCPCS Level II updates for COVID-19 products.

Why This Topic Matters

COVID-19 treatment coding has changed quickly in response to evolving authorizations and outpatient use cases. Keeping current helps organizations align billing, charge capture, and documentation workflows with the latest HCPCS Level II updates.

Article Sections

  1. New HCPCS code for convalescent plasma for COVID-19 in the outpatient setting

    Discusses an FDA emergency use authorization update and a newly established HCPCS Level II code tied to outpatient use of a COVID-19 plasma product. The section also provides the effective date and general context for the treatment.

  2. New monoclonal antibody treatment for COVID-19

    Reviews the FDA authorization update for a monoclonal antibody treatment and the related HCPCS Level II coding additions. It includes the effective date and broad outpatient treatment context.

  3. Revised emergency use authorization for Evusheld™

    Summarizes an FDA EUA revision and the corresponding CMS coding update for a pre-exposure prophylaxis product. The section notes the related administration code context and the effective date.

What You Will Learn

  • Which COVID-19 treatment categories were updated in response to FDA EUA changes
  • How the article organizes recent HCPCS Level II additions for outpatient COVID-19 therapies
  • What general types of effective-date and authorization information are included
  • How CMS and FDA actions are connected in COVID-19 treatment coding updates

Who Should Read This

  • Medical coders
  • Billing staff
  • Revenue cycle teams
  • Compliance professionals
  • Health information management staff
  • Outpatient clinic administrators

Codes Discussed


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