New CPT codes for Proprietary Laboratory Analyses (PLA)

There are several new Proprietary Laboratory Analyses (PLA) codes established by the American Medical Association (AMA) that are now available for reporting. These new PLA codes, their code descriptors and effective dates, are listed in the table below. CPT Code Long Descriptor Effective Date 0004U Infectious disease (bacterial), DNA, 27 resistance genes, PCR amplification and probe hybridization in microarray format (molecular detection and identification of AmpC, carbapenemase and ESBL coding genes), bacterial culture colonies, report of genes detected or not detected, per isolate   January 1, 2018 0015U Drug metabolism (adverse drug reactions), DNA, 22 drug metabolism and transporter...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article reviews a set of newly established American Medical Association Proprietary Laboratory Analyses (PLA) CPT codes and when they became available for reporting. It is relevant to laboratory billing, pathology, molecular diagnostics, and other clinical specialties that use PLA testing. The article is organized as a code listing with descriptors and effective dates, helping readers identify which new PLA entries are included in the update.

Why This Topic Matters

PLA code updates affect laboratory reporting, test identification, and coding reference workflows across multiple specialties. Knowing which new CPT PLA codes were established and when they took effect helps coding teams, labs, and compliance staff review their reporting resources against the latest update.

What You Will Learn

  • Which new PLA code entries are included in the update
  • How the article is organized around CPT code listings and effective dates
  • Which clinical and laboratory subject areas are represented in the new PLA set
  • The scope of the 2018 PLA additions covered by the article

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Pathology professionals
  • Clinical laboratory managers
  • Compliance staff
  • Revenue cycle teams

Codes Discussed


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