New CPT proprietary lab analysis (PLA) codes

Effective October 1 2019, there was 1 PLA code deleted and 34 PLA codes added Deleted PLA code: CPT Code Long Descriptor Effective Date 0104U Hereditary pan cancer (e.g., hereditary breast and ovarian cancer, hereditary endometrial cancer, hereditary colorectal cancer), genomic sequence analysis panel utilizing a combination of NGS, Sanger, MLPA, and array CGH, with MRNA analytics to resolve variants of unknown significance when indicated (32 genes [sequencing and deletion/duplication], EPCAM and GREM1 [deletion/duplication only]) October 1, 2019   New PLA codes: CPT Code Long Descriptor Effective Date 0105U Nephrology (chronic kidney disease), multiplex electrochemiluminescent immunoassay (ECLIA) of...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This reference page covers a CPT proprietary laboratory analysis (PLA) code change set effective October 1, 2019. It is useful for coding professionals, laboratory teams, and revenue cycle staff who need to track newly added and deleted PLA codes and understand the broad clinical and testing areas represented in the update.

Why This Topic Matters

PLA code changes can affect lab test reporting, charge capture, and code maintenance workflows. Reviewing the update helps stakeholders identify which laboratory offerings were added or removed and assess whether their documentation, billing, or test catalogs need revision.

What You Will Learn

  • The scope of a CPT PLA code update and its effective date.
  • Which broad clinical and laboratory service areas were included in the update.
  • How deleted and newly added PLA codes are presented in a coding reference format.
  • Which specialties and test categories are represented across the new PLA code list.

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Revenue cycle professionals
  • Pathology and clinical laboratory teams
  • Health information management professionals

Codes Discussed


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