New CPT Proprietary Laboratory Analyses (PLA) codes Effective April 1, 2026

New CPT PLA Codes CPT Code Long Descriptor Effective Date 0614U Inborn error of metabolism (primary mitochondrial disease), mitochondrial analysis of 4 enzyme complexes by stained blue native polyacrylamide gel electrophoresis (PAGE), frozen tissue (muscle, liver, heart, cultured skin fibroblasts), diagnostic qualitative result April 1, 2026 0615U Borrelia burgdorferi (Lyme disease), antibody detection of 26 recombinant protein groups, by immunoassay, IgM April 1, 2026 0616U Neurology (dementia), DNA methylation analysis of more than 30,000 sites, whole blood, algorithm reported as positive or negative risk April 1, 2026 0617U Cardiovascular (atherosclerotic cardiovascular disease [ASCVD]), DNA methylation analysis of more...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article presents newly effective CPT Proprietary Laboratory Analyses (PLA) codes for April 1, 2026. It is useful for coding professionals, laboratory billers, compliance teams, and reimbursement staff who need to track additions to the CPT PLA code set and understand the broad clinical areas these new laboratory tests relate to. The article focuses on code identifiers, effective timing, and the general testing categories represented across infectious disease, oncology, neurology, psychiatry, cardiology, hepatology, nephrology, endocrine, pulmonary, and autoimmune medicine.

Why This Topic Matters

PLA code updates can affect laboratory billing workflows, claims processing, and coding system maintenance. Tracking new effective codes helps organizations stay current with CPT updates and identify which service lines may be impacted.

Article Sections

  1. New CPT PLA Codes

    A table of newly effective CPT PLA identifiers with their effective date and broad clinical categories. The entries span several specialties and laboratory testing methods.

What You Will Learn

  • Which broad clinical areas are represented among the newly effective CPT PLA additions
  • How the article is organized around new code listings and effective dates
  • What types of laboratory testing categories are included in the update
  • Which professional audiences should monitor these CPT PLA changes

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance teams
  • Revenue cycle professionals
  • Payer contracting staff
  • Clinical laboratory administrators

Codes Discussed


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