New CPT Proprietary Laboratory Analyses (PLA) Codes

New, Deleted, and Revised CPT Proprietary Laboratory Analyses (PLA) codes Effective July 1, 2026 Newly released changes to the CPT Proprietary Laboratory Analyses codes consist of the addition of 29 codes, deletion of 4 codes, and the revision of 2 codes. New CPT PLA Codes CPT Code Long Descriptor Effective Date 0631U Oncology (solid tumor), DNA, sequence analysis of 15 genes including BRCA1 and BRCA2 for identification of clonal hematopoiesis, blood, reported as tumor-derived or nontumor-derived July 1, 2026 0632U Red blood cell antigen (fetal RhD gene analysis), multiplex polymerase chain reaction (PCR) and next-generation sequencing (NGS) of circulating...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This page reviews a CPT PLA code update effective July 1, 2026. It is intended for coding professionals, laboratory billing teams, and compliance staff who need a concise view of newly added, deleted, and revised PLA entries and the broad clinical areas they affect.

Why This Topic Matters

PLA code changes can affect laboratory reporting, claim accuracy, and internal coding workflows. Tracking these updates helps organizations stay aligned with current CPT laboratory coding publications and prepare for implementation dates.

Article Sections

  1. New CPT PLA Codes

    Lists the newly released PLA entries and groups them by broad clinical domain. This section presents the effective date and the general scope of each new laboratory service.

  2. Deleted CPT PLA Codes

    Identifies PLA entries scheduled for deletion and notes their effective date. This section supports awareness of code set maintenance changes.

  3. Revised CPT PLA Codes

    Summarizes the PLA entries that were revised for the effective date shown. This section is limited to updated laboratory code entries.

What You Will Learn

  • Which PLA codes were added, deleted, or revised for the July 1, 2026 update
  • Which broad clinical areas are represented in the new PLA entries
  • How to recognize the scope of the update as a CPT laboratory code maintenance release
  • Which PLA entries are affected by the effective date change

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance teams
  • Revenue cycle professionals
  • Health information management professionals

Codes Discussed


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