New and Deleted CPT Proprietary Laboratory Analyses (PLA) Codes

New and deleted CPT PLA codes effective April 1, 2024 New CPT PLA codes CPT Code Long Descriptor Effective Date 0439U Cardiology (coronary heart disease [CHD]), DNA, analysis of 5 single-nucleotide polymorphisms (SNPs) (rs11716050 [LOC105376934], rs6560711 [WDR37], rs3735222 [SCIN/LOC107986769], rs6820447 [intergenic], and rs9638144 [ESYT2]) and 3 DNA methylation markers (cg00300879 [transcription start site {TSS200} of CNKSR1], cg09552548 [intergenic], and cg14789911 [body of SPATC1L]), qPCR and digital PCR, whole blood, algorithm reported as a 4-tiered risk score for a 3-year risk of symptomatic CHD April 1, 2024 0440U Cardiology (coronary heart disease [CHD]), DNA, analysis of 10 single-nucleotide polymorphisms (SNPs)...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article is a code-update summary for CPT Proprietary Laboratory Analyses (PLA) codes, covering new and deleted entries effective April 1, 2024 and July 1, 2024. It is useful for laboratory billing, coding, and compliance teams that track quarterly CPT PLA changes across specialties such as cardiology, oncology, infectious disease, autoimmune disease, genetics, and other diagnostic testing areas. The article presents the affected code sets and effective dates so readers can identify which PLA updates are relevant to their workflow.

Why This Topic Matters

PLA code updates affect how specialized laboratory tests are reported and tracked in current coding workflows. Knowing which codes were added or removed helps coding and reimbursement teams maintain accurate reference materials and stay aligned with effective-date changes.

Article Sections

  1. New CPT PLA codes effective April 1, 2024

    Introduces the newly effective PLA codes for this date. The section groups additions by clinical area and laboratory method.

  2. Deleted CPT PLA codes effective April 1, 2024

    Lists PLA codes removed on this date. The section supports reference updates for laboratory and billing workflows.

  3. New and deleted CPT Proprietary Laboratory Analyses (PLA) codes effective July 1, 2024

    Begins the second update cycle covered by the article and frames the July 2024 PLA changes.

  4. New CPT PLA codes

    Presents the added PLA codes for the July 2024 update. The entries span several diagnostic specialties and assay types.

  5. Deleted CPT PLA codes

    Identifies PLA codes deleted in the July 2024 update. The list supports maintaining current code references.

What You Will Learn

  • Which CPT PLA codes were added for April 2024 and July 2024
  • Which CPT PLA codes were deleted for April 2024 and July 2024
  • The broad clinical areas represented in the PLA update
  • The effective dates associated with the listed PLA code changes
  • The types of laboratory methods and specimen sources covered by the update

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance teams
  • Revenue cycle professionals
  • Practice managers
  • Healthcare administrators

Codes Discussed


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