New, deleted and revised CPT PLA codes

New CPT PLA codes CPT Code Long Descriptor Effective Date 0364U Oncology (hematolymphoid neoplasm), genomic sequence analysis using multiplex (PCR) and next-generation sequencing with algorithm, quantification of dominant clonal sequence(s), reported as presence or absence of minimal residual disease (MRD) with quantitation of disease burden, when appropriate April 1, 2023 0365U Oncology (bladder), analysis of 10 protein biomarkers (A1AT, ANG, APOE, CA9, IL8, MMP9, MMP10, PAI1, SDC1 and VEGFA) by immunoassays, urine, algorithm reported as a probability of bladder cancer April 1, 2023 0366U Oncology (bladder), analysis of 10 protein biomarkers (A1AT, ANG, APOE, CA9, IL8, MMP9, MMP10, PAI1...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This page is a coding update summary for CPT Proprietary Laboratory Analyses (PLA) codes effective April 1, 2023. It is aimed at coding professionals, billers, and compliance staff who need to track new, deleted, and revised laboratory assay and molecular testing code entries. The article presents the affected code listings and updated descriptors across oncology, infectious disease, nephrology, gastroenterology, and related testing categories.

Why This Topic Matters

PLA code updates can affect laboratory test reporting, code maintenance, and claims accuracy. Reviewing these changes helps users stay current with the latest CPT PLA additions, deletions, and descriptor revisions.

Article Sections

  1. New CPT PLA codes

    Lists newly established CPT PLA entries effective April 1, 2023 across multiple testing categories. The section organizes the additions by code and general clinical area.

  2. Deleted CPT PLA codes

    Identifies CPT PLA entries scheduled for deletion effective April 1, 2023. The section provides the affected code listings for maintenance and reference.

  3. Revised CPT PLA codes

    Presents updated CPT PLA descriptors for existing codes effective April 1, 2023. The section shows the prior and revised wording for comparison.

What You Will Learn

  • Which CPT PLA codes were added, deleted, or revised in the April 1, 2023 update.
  • What broad clinical categories are represented in the update.
  • How the article is organized for reference to PLA code maintenance changes.
  • Which entries are tied to the April 1, 2023 effective date.

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance teams
  • Revenue cycle staff
  • Coding managers

Codes Discussed


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