New, deleted and revised CPT Proprietary Laboratory Analyses (PLA) codes effective January 1, 2025

New CPT PLA codes CPT Code Long Descriptor Effective Date 0521U Rheumatoid factor IgA and IgM, cyclic citrullinated peptide (CCP) antibodies, and scavenger receptor A (SR-A) by immunoassay, blood January 1, 2025 0522U Carbonic anhydrase VI, parotid specific/secretory protein and salivary protein 1 (SP1), IgG, IgM, and IgA antibodies, chemiluminescence, semiqualitative, blood January 1, 2025 0523U Oncology (solid tumor), DNA, qualitative, next-generation sequencing (NGS) of single nucleotide variants (SNV) and insertion/deletions in 22 genes utilizing formalin-fixed paraffin-embedded tissue, reported as presence or absence of mutation(s), location of mutation(s), nucleotide change, and amino acid change January 1, 2025 0524U Obstetrics...

Subscribe or sign in to view the full article.

Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article provides a structured overview of CPT Proprietary Laboratory Analyses (PLA) code changes effective January 1, 2025. It is useful for coders, billing professionals, laboratory teams, and compliance staff who need to track newly added, removed, and updated PLA entries spanning immunology, oncology, obstetrics, nephrology, infectious disease, hematology, autoimmune testing, and other laboratory-focused specialties. The article presents the affected code set, the timing of the changes, and the broad clinical categories covered by the updates.

Why This Topic Matters

PLA code changes can affect claim reporting, laboratory test catalogs, and internal coding references. Reviewing these updates helps organizations stay aligned with the current CPT PLA landscape and identify which laboratory services are affected by the 2025 changes.

Article Sections

  1. New CPT PLA codes

    Lists newly effective PLA entries and the broad clinical areas they cover. The section organizes the additions by test category and effective date.

  2. Deleted CPT PLA codes

    Summarizes PLA entries removed effective the same date. It identifies the affected laboratory testing areas and provides the deletion timing.

  3. Revised CPT PLA codes

    Describes PLA entries that were updated rather than added or removed. The section compares the prior and revised wording and shows the effective date of the revision.

What You Will Learn

  • Which PLA code entries were added for 2025
  • Which PLA code entries were deleted for 2025
  • Which PLA code entries were revised for 2025
  • What broad laboratory and clinical subject areas are affected by the update
  • How the article organizes PLA changes by status and effective date

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance professionals
  • Revenue cycle teams
  • Pathology and molecular diagnostics staff
  • Healthcare administrators

Codes Discussed


Subscribe or sign in to view the full article.

The AHA Coding Clinic for HCPCS includes:

  • The official publication for Level I HCPCS (CPT-4 codes) for hospital providers
  • Also specific Level II HCPCS codes for hospitals, physicians and other health professionals
  • Current newsletters added each quarter
  • Full Archives back to 2001
  • Fully searchable through Find-A-Code's Comprehensive Search
  • Codes mentioned in articles are linked to Code Information pages
  • Code Information page link back to related articles
  • View all the articles associated with any code, right from the code page!
Access to this feature is available in the following products:
  • AHA's Coding Clinic® - HCPCS +Archives

Related Articles

Articles are listed in order of calculated relevance.

demo
request yours today
subscribe
start today
newsletter
free subscription

Thank you for choosing Find-A-Code, please Sign In to remove ads.

Aimee- AI -powered coding assistant - Try it now for Free Would you like Aimee - AI
to help you with this?