New, deleted and revised CPT Proprietary Laboratory Analyses (PLA) codes effective July 1, 2025

The most recent changes to the CPT PLA codes include 23 additions, 6 deletions, and 1 revision.  New CPT PLA codes CPT Code Long Descriptor Effective Date 0552U Reproductive medicine (preimplantation genetic assessment), analysis for known genetic disorders from trophectoderm biopsy, linkage analysis of disease causing locus, and when possible, targeted mutation analysis for known familial variant, reported as low-risk or high-risk for familial genetic disorder July 1, 2025 0553U Reproductive medicine (preimplantation genetic assessment), analysis of 24 chromosomes using DNA genomic sequence analysis from embryonic trophectoderm for structural rearrangements, aneuploidy, and a mitochondrial DNA score, results reported...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article reviews a July 1, 2025 update to CPT Proprietary Laboratory Analyses (PLA) codes. It is useful for coding professionals, laboratory staff, and revenue cycle teams who need to track annual code set changes affecting molecular diagnostics, oncology, infectious disease, neurology, reproductive medicine, and other specialty testing areas. The article provides a high-level list of new, deleted, and revised PLA entries and helps readers identify which lab-testing categories are affected by the update.

Why This Topic Matters

PLA code updates can affect test reporting, code maintenance, and charge capture workflows. Staying current helps teams recognize which laboratory methods and clinical categories were changed in the July 1, 2025 CPT PLA update.

Article Sections

  1. New CPT PLA codes

    Lists newly added PLA entries and the broad clinical testing areas they cover across multiple specialties. The section presents the update as effective July 1, 2025.

  2. Deleted CPT PLA codes

    Identifies PLA entries that were removed in the July 1, 2025 update. The section organizes the deletions by broad laboratory and infectious disease testing categories.

  3. Revised CPT PLA codes

    Summarizes the PLA entry that was revised in this update. The section notes the effective date and the general oncology monitoring context.

What You Will Learn

  • Which broad clinical areas were affected by the July 1, 2025 CPT PLA update
  • How the article groups PLA changes into additions, deletions, and revisions
  • Which specialty testing categories are represented in the update
  • What types of laboratory methods are included in the revised PLA set

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Pathology and molecular diagnostics teams
  • Revenue cycle professionals
  • Compliance staff

Codes Discussed


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