New, deleted, and revised CPT Proprietary Laboratory Analyses (PLA) codes effective October 1, 2025

The most recent changes to the CPT PLA codes include 25 additions, 2 deletions and 2 revisions.  New CPT PLA codes CPT Code Long Descriptor Effective Date 0575U Transplantation medicine (liver allograft rejection), miRNA gene expression profiling by RT-PCR of 4 genes (miR-122, miR-885, miR-23a housekeeping, spike-in control), serum, algorithm reported as risk of liver allograft rejection October 1, 2025 0576U Transplantation medicine (liver allograft rejection), quantitative donor-derived cell-free DNA (cfDNA) by whole genome next-generation sequencing, plasma and mRNA gene expression profiling by multiplex real-time PCR of 56 genes, whole blood, combined algorithm reported as a rejection risk...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article reviews a CPT Proprietary Laboratory Analyses (PLA) code update effective October 1, 2025. It is useful for laboratory billing, coding, compliance, and reimbursement teams that track annual code maintenance. The content focuses on newly added PLA codes, deleted PLA codes, and revised PLA code descriptors, along with their effective dates and related AMA release information.

Why This Topic Matters

PLA code updates can affect laboratory test reporting, claim accuracy, and code maintenance workflows. Keeping current with additions, deletions, and revisions helps reduce denials and supports correct coding for specialized molecular, genetic, and biomarker-based tests.

Article Sections

  1. New CPT PLA codes

    Lists newly added PLA codes effective October 1, 2025 and groups them by clinical area. The section presents the code maintenance update for multiple specialty and laboratory testing categories.

  2. Deleted CPT PLA codes

    Identifies PLA codes removed from the current code set effective October 1, 2025. The section provides the deleted entries and their maintenance context.

  3. Revised CPT PLA codes

    Summarizes PLA codes with updated long descriptors and related release timing. The section highlights the code maintenance changes for existing entries.

What You Will Learn

  • What categories of CPT PLA code changes are included in the October 1, 2025 update
  • Which types of laboratory and diagnostic specialties are represented in the update
  • How the article organizes new, deleted, and revised PLA entries
  • What effective-date information accompanies the listed PLA maintenance changes

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance teams
  • Revenue cycle professionals
  • Pathology and molecular diagnostics teams
  • Coding educators

Codes Discussed


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