New, Deleted, and Revised CPT Proprietary Laboratory Analyses (PLA) codes Effective October 1, 2026

Newly released changes to the CPT Proprietary Laboratory Analyses codes consist of the addition of 39 codes, deletion of 3 codes, and the revision of 3 codes. New CPT PLA Codes CPT Code Long Descriptor Effective Date 0660U Human papillomavirus (HPV), genotypes 18, 31, 33, and 35, cell-free DNA (cfDNA), whole blood, multiplex digital droplet PCR (ddPCR), quantitative October 1, 2026 0661U Human papillomavirus (HPV), genotype 16, cell-free DNA (cfDNA), whole blood, digital droplet PCR (ddPCR), quantitative October 1, 2026 0662U Transplantation medicine (kidney allograft rejection), mRNA, gene-expression profiling by real-time quantitative PCR of 12 genes (11 content and...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article summarizes changes to the CPT Proprietary Laboratory Analyses code set effective October 1, 2026. It organizes the updates into new, deleted, and revised codes, with coverage spanning laboratory testing in areas such as oncology, infectious disease, genetics, transplantation medicine, and other clinical fields.

Why This Topic Matters

Keeping track of effective-date changes to laboratory analysis codes can help coding professionals and laboratory teams identify updates relevant to their work and determine whether to review the full code-level material.

Article Sections

  1. New CPT PLA Codes

    This section covers newly added CPT PLA codes effective October 1, 2026, across a range of laboratory testing topics and clinical areas.

  2. Deleted CPT PLA Codes

    This section covers CPT PLA codes scheduled for deletion effective October 1, 2026, in infectious disease and oncology testing.

  3. Revised CPT PLA Codes

    This section covers revisions to CPT PLA codes effective October 1, 2026, in obstetrics, transplantation medicine, and oncology.

What You Will Learn

  • Which categories of CPT PLA updates take effect on October 1, 2026.
  • The clinical and laboratory testing areas represented in the new-code updates.
  • Which areas are represented in the deletion and revision updates.
  • intended_audiences

Who Should Read This

  • Medical coders
  • Laboratory coding and billing professionals
  • Clinical laboratory staff
  • Healthcare revenue cycle professionals

Codes Discussed


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