New, deleted and revised HCPCS Level II codes effective July 1, 2025

The Centers for Medicare and Medicaid Services updates the HCPCS Level II code set quarterly. Only a subset of the code changes effective July 1, 2025, have been provided here. For a full listing of the code changes, see the HCPCS Quarterly Update file at: https://www.cms.gov/medicare/coding-billing/healthcare-common-procedure-system/quarterly-update . New HCPCS Level II codes HCPCS Level II Code Long Descriptor Effective Date C9174 Injection, datopotamab deruxtecan-dlnk, 1 mg July 1, 2025 C9175 Injection, treosulfan, 50 mg July 1, 2025 J0165 Injection, epinephrine, not otherwise specified, 0.1 mg July 1, 2025 J0166 Injection, epinephrine (BPI), not therapeutically equivalent to J0165...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This page is a coding update on selected HCPCS Level II changes effective July 1, 2025. It is useful for coders, billers, compliance staff, and other revenue cycle professionals who track quarterly CMS updates and need to stay current on newly added, deleted, and revised HCPCS Level II entries. The article presents a partial listing from the quarterly update file and organizes the changes by status so readers can quickly identify what areas of the code set were affected.

Why This Topic Matters

Quarterly HCPCS updates can affect charge capture, claims processing, and internal reference files. Reviewing the change list helps coding teams recognize which portions of the HCPCS Level II set were updated for the effective date and where to look for the official CMS listing.

Article Sections

  1. New HCPCS Level II codes

    This section lists newly effective HCPCS Level II entries for the July 2025 quarterly update. It covers multiple categories of newly added services and products referenced in the article.

  2. Deleted HCPCS Level II codes

    This section identifies HCPCS Level II entries scheduled for deletion effective July 1, 2025. It reflects the subset of deletions included in the article.

  3. Revised HCPCS Level II codes

    This section summarizes HCPCS Level II codes with revised descriptors effective July 1, 2025. It presents the source's before-and-after update format for selected entries.

What You Will Learn

  • How the July 1, 2025 HCPCS Level II quarterly update is organized
  • Which entries were newly added, deleted, or revised in the selected listing
  • How CMS presents selected code-set changes in a quarterly update notice
  • What types of HCPCS Level II changes may affect coding reference materials and claims workflows

Who Should Read This

  • Medical coders
  • Billing professionals
  • Revenue cycle staff
  • Compliance teams
  • Practice administrators
  • Health information management professionals

Codes Discussed


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