New, Deleted and Revised HCPCS Level II Codes Effective October 1, 2025

The Centers for Medicare and Medicaid Services updates the HCPCS Level II code set quarterly. Only a subset of the code changes effective October 1, 2025, have been provided here. For a full listing of the code changes, see the HCPCS Quarterly Update file at https://www.cms.gov/medicare/coding-billing/healthcare-common-procedure-system/quarterly-update . New HCPCS Level II Codes HCPCS Level II Code Long Descriptor Effective Date A2036 Cohealyx Collagen Dermal Matrix, per square centimeter (add-on, list separately in addition to primary procedure) October 1, 2025 A2037 G4Derm Plus, per milliliter October 1, 2025 A2038 MariGen Pacto, per square centimeter (add-on, list separately in addition...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article reviews selected CMS HCPCS Level II quarterly updates effective October 1, 2025. It is useful for coders, billers, compliance staff, and reimbursement teams who need to track newly created, deleted, and revised HCPCS Level II entries and understand the scope of the changes covered in this update.

Why This Topic Matters

Quarterly HCPCS Level II updates can affect charge capture, claim submission, and code set maintenance. This summary helps readers quickly determine whether the premium article covers the kinds of HCPCS changes they need to monitor for October 2025.

Article Sections

  1. New HCPCS Level II Codes

    This section lists newly effective HCPCS Level II entries for the quarter. It covers a mix of pharmaceuticals, supplies, devices, implants, and other reportable items.

  2. Deleted HCPCS Level II Codes

    This section identifies HCPCS Level II entries removed effective the same date. It supports code set maintenance and review of quarterly deletions.

  3. Revised HCPCS Level II Codes

    This section presents selected HCPCS Level II revisions effective October 1, 2025. It focuses on codes whose descriptors were updated for the quarterly cycle.

What You Will Learn

  • What types of HCPCS Level II changes are included in the October 2025 quarterly update
  • How the article is organized across new, deleted, and revised code listings
  • Which broad service categories are represented in the update
  • How selected HCPCS Level II changes are grouped by effective date

Who Should Read This

  • Medical coders
  • Medical billing staff
  • Compliance professionals
  • Revenue cycle teams
  • Payer and reimbursement analysts

Codes Discussed


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The AHA Coding Clinic for HCPCS includes:

  • The official publication for Level I HCPCS (CPT-4 codes) for hospital providers
  • Also specific Level II HCPCS codes for hospitals, physicians and other health professionals
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  • Fully searchable through Find-A-Code's Comprehensive Search
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Access to this feature is available in the following products:
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