New PLA Codes

New Proprietary Laboratory Analyses (PLA) codes effective October 1, 2022 CPT Code Long Descriptor Effective Date 0332U Oncology (pan-tumor), genetic profiling of 8 DNAregulatory (epigenetic) markers by quantitative polymerase chain reaction (qPCR), whole blood, reported as a high or low probability of responding to immune checkpoint–inhibitor therapy October 1, 2022 0333U Oncology (liver), surveillance for hepatocellular carcinoma (HCC) in high-risk patients, analysis of methylation patterns on circulating cell-free DNA (cfDNA) plus measurement of serum of AFP/AFP-L3 and oncoprotein des-gammacarboxy-prothrombin (DCP), algorithm reported as normal or abnormal result October 1, 2022 0334U Oncology (solid organ), targeted genomic sequence analysis...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This page is a premium coding reference covering new Proprietary Laboratory Analyses (PLA) CPT codes effective October 1, 2022. It is useful for coding professionals, laboratory billing staff, compliance teams, and specialty practices that need to track newly added molecular, genetic, infectious disease, and biomarker-based laboratory assays. The article provides the code list along with broad descriptor information and effective-date context so readers can identify which new PLA codes are relevant to their workflow.

Why This Topic Matters

PLA codes change how emerging laboratory tests are reported and tracked, so staying current helps coding, billing, and reimbursement teams recognize newly available assay categories and maintain accurate lab claim reporting.

Article Sections

  1. New Proprietary Laboratory Analyses (PLA) codes effective October 1, 2022

    Introduces the set of newly effective PLA laboratory codes and frames the article as an update notice. The section presents the broad coverage areas represented in the list.

What You Will Learn

  • What the article covers in terms of newly effective PLA code updates
  • Which general clinical areas are represented in the new PLA code list
  • How the article is organized around effective-date information for laboratory reporting
  • Which specialties and test categories are included in the update

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance and reimbursement teams
  • Clinical laboratorians
  • Specialty practice administrators

Codes Discussed


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