New PLA Codes

New CPT Proprietary Laboratory Analyses (PLA) codes effective January 1, 2023 CPT Code Long Descriptor Effective Date 0355U APOL1 (apolipoprotein L1) (eg, chronic kidney disease), risk variants (G1, G2) January 1, 2023 0356U Oncology (oropharyngeal), evaluation of 17 DNA biomarkers using droplet digital PCR (ddPCR), cell-free DNA, algorithm reported as a prognostic risk score for cancer recurrence January 1, 2023 0357U Oncology (melanoma), artificial intelligence (AI)- enabled quantitative mass spectrometry analysis of 142 unique pairs of glycopeptide and product fragments, plasma, prognostic, and predictive algorithm reported as likely, unlikely, or uncertain benefit from immunotherapy agents January 1, 2023 0358U...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article provides a high-level overview of new CPT Proprietary Laboratory Analyses (PLA) codes effective in 2023. It is useful for coding professionals, laboratory billing teams, and compliance staff who need to understand the scope of the new molecular, genomic, proteomic, and biomarker-based tests included in the update. The article presents the new code entries with their effective date and broad clinical focus areas.

Why This Topic Matters

PLA code updates affect how specialized laboratory tests are identified and tracked in coding workflows. Knowing which new tests were added helps organizations review test catalogs, billing systems, and coding references for the applicable year.

What You Will Learn

  • Which broad clinical areas are represented in the new PLA code update
  • How the article organizes the new CPT PLA code entries
  • What types of laboratory testing technologies are included at a high level
  • The effective date associated with the listed updates

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance professionals
  • Revenue cycle staff
  • Pathology and laboratory medicine teams

Codes Discussed


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