New and Revised CPT Proprietary Laboratory Analyses (PLA) Codes

New and revised CPT Proprietary Laboratory Analyses (PLA) codes effective January 1, 2024 New CPT PLA codes CPT Code Long Descriptor Effective Date 0420U Oncology (urothelial), mRNA expression profiling by real-time quantitative PCR of MDK, HOXA13, CDC2, IGFBP5, and CXCR2 in combination with droplet digital PCR (ddPCR) analysis of 6 single-nucleotide polymorphisms (SNPs) genes TERT and FGFR3, urine, algorithm reported as a risk score for urothelial carcinoma January 1, 2024 0421U Oncology (colorectal) screening, quantitative real-time target and signal amplification of 8 RNA markers (GAPDH, SMAD4, ACY1, AREG, CDH1, KRAS, TNFRSF10B, EGLN2) and fecal hemoglobin, algorithm reported as a...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article covers CPT Proprietary Laboratory Analyses (PLA) code updates effective January 1, 2024. It is relevant to laboratory coders, billing teams, compliance staff, and other professionals who track CPT PLA changes. The article presents newly created PLA codes and revisions to existing PLA code descriptors, along with the effective date information needed to monitor current laboratory coding references.

Why This Topic Matters

PLA code updates can affect laboratory billing, coding reference materials, and internal charge capture processes. Tracking these changes helps organizations stay aligned with the current CPT PLA set and understand which code entries were added or revised for 2024.

Article Sections

  1. New CPT PLA codes

    This section lists newly established CPT PLA entries effective for January 1, 2024. It presents a range of laboratory, oncology, psychiatry, genomics, and other specialty categories covered by the update.

  2. Revised CPT PLA codes

    This section identifies existing CPT PLA entries that were revised effective January 1, 2024. It shows the updated descriptor information for the affected codes.

What You Will Learn

  • Which CPT PLA codes were newly added for 2024
  • Which existing CPT PLA codes were revised for 2024
  • How the article is organized by new versus revised PLA code updates
  • Which general clinical and laboratory categories are represented in the update

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance professionals
  • Revenue cycle staff
  • Coding managers

Codes Discussed


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