Reporting for the Cologuard test

The Cologuard test is the first stool-based colorectal screening test able to detect the presence of red blood cells and DNA mutations that may indicate the presence of certain abnormal growths which may be cancerous, such as, colon cancer or precursors to cancer. As of January 1, 2016, the Cologuard test should be reported with CPT code 81528 , Oncology (colorectal) screening , quantitative real-time target and signal amplification of 10 DNA markers ( KRAS mutations, promoter methylation of NDRG4 and BMP3 ) and fecal hemoglobin, utilizing stool, algorithm reported as a positive or negative result. ...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This short coding article focuses on reporting guidance for the Cologuard stool-based colorectal screening test. It is aimed at coding, billing, and compliance professionals who need a quick reference for the relevant CPT reporting approach and the effective date mentioned in the article.

Why This Topic Matters

Correct reporting of this colorectal screening service affects claims accuracy, consistent coding, and alignment with current guidance.

What You Will Learn

  • The general purpose of the Cologuard colorectal screening test
  • Which coding area the article addresses
  • The effective date associated with the reporting guidance
  • How the article frames the test in relation to colorectal screening reporting

Who Should Read This

  • Medical coders
  • Billing staff
  • Compliance professionals
  • Revenue cycle teams
  • Clinical documentation specialists

Codes Discussed


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