AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2020 Issue 1; Clarification

Cytokine Release Syndrome

There has been some confusion regarding advice published in Coding Clinic, Second Quarter 2019 page 24, for cytokine release syndrome (CRS). The advice states to assign code E88.3, Tumor lysis syndrome, for CRS. However, code assignment for CRS may not be the same in every case, as some patients may not present with tumor lysis syndrome. Therefore, code assignment for CRS would be based on the specific manifestations documented by the provider. As previously stated, this advice is supported by the guideline stating in the absence of Alphabetic Index guidance, assign codes for the documented manifestations of the...

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