AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2020 Issue 4; New/Revised ICD-10-CM Codes

Cytokine Release Syndrome

Codes have been created for cytokine release syndrome (CRS) that distinguish grades of severity. CRS and cytokine storm syndrome (CSS) are used synonymously in literature. CRS is a systemic inflammatory response to infections and certain immunotherapies, such as monoclonal antibodies and chimeric antigen receptor (CAR) T-cell therapy that cause activation of the immune system. Lymphocytes and/or myeloid cells cause a massive and rapid release of cytokines into the blood. Cytokines are small proteins that act as cell messengers to help direct the body’s immune response. The reaction to the cytokine release ranges from mild symptoms to life-threatening organ...

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