AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2016 Issue 4; ICD-10-CM NEW/REVISED CODES

Mast Cell Activation Syndromes

A new subcategory D89.4, Mast cell activation syndrome and related disorders, has been created with five new codes to specifically identify mast cell activation. Mast cell activation is found in a number of allergic reactions and is also caused by various other disorders. Mast cell activation syndrome (MCAS) in general involves hyper-responsive mast cells (there is a normal number of cells, however they react abnormally), as opposed to hyperproliferative mast cells (as is seen with mastocytosis). Symptoms associated with MCAS may include, but are not limited to, flushing, pruritus, urticaria, headache, gastrointestinal symptoms (including diarrhea, nausea, vomiting, abdominal...

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