CPT Knowledgebase - Jan 11, 2016

Does code 81420 encompass genomic sequence analysis involving single nucleotide polymorphism (SNPs) (hot spots) only or does the code include only full sequencing tests? Is it appropriate to report molecular cytogenetic codes (eg, FISH) for microdeletion testing that involves deeper sequence analysis of circulating cell-free DNA rather than in situ analysis of cells for trisomy 21, 18, and 13?

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