Abnormal Prion Protein [Presence] in Cerebral spinal fluid by RT-QuIC 101662-5
LOINC Code
| LOINC code | 101662-5 | ||
|---|---|---|---|
| name | Abnormal Prion Protein [Presence] in Cerebral spinal fluid by RT-QuIC | ||
| description | Detection of pathologic prions in cerebrospinal fluid (CSF). The test uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the patient's CSF, they propagate misfolding of the reagent PrP to form amyloid, which is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The reported sensitivity of RT-QuIC in detecting CJD is >90%, and the specificity approaches 100%. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Prion protein.abnormal | ||
| property | PrThr = Present or threshold: The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold. | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | CSF = Cerebral spinal fluid | ||
| scale | Ord = Ordinal: Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive. | ||
| method | RT-QuIC | ||
Additional Names | |||
| short name | Abn Prion Prot CSF Ql RT-QuIC | ||
Basic Attributes | |||
| class | CHEM | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.75 | ||
| last change type | ADD - added | ||
Related Names | |||
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