Abnormal Prion Protein [Presence] in Cerebral spinal fluid by RT-QuIC   101662-5

LOINC Code


LOINC code101662-5
nameAbnormal Prion Protein [Presence] in Cerebral spinal fluid by RT-QuIC
descriptionDetection of pathologic prions in cerebrospinal fluid (CSF). The test uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the patient's CSF, they propagate misfolding of the reagent PrP to form amyloid, which is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The reported sensitivity of RT-QuIC in detecting CJD is >90%, and the specificity approaches 100%.
statusACTIVE

Fully-Specified Name

componentPrion protein.abnormal
propertyPrThr  =  Present or threshold:  The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold.
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemCSF  =  Cerebral spinal fluid
scaleOrd  =  Ordinal:  Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive.
methodRT-QuIC

Additional Names

short nameAbn Prion Prot CSF Ql RT-QuIC

Basic Attributes

classCHEM
type1  Laboratory
order vs. observationBoth

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

History/Usage

first released
last updated2.75
last change typeADD  - added

Related Names

abn
Abn Prion Prot
abnorm
Bovine spongiform encephalopathy
BSE
Cerebral spinal fluid
Cerebrospinal Fl
Chemistry
Ordinal
Point in time
PR
Prot
PrP
QL
Qual
Qualitative
Random
Scrapie
Screen
Spinal Fl
Spinal Fld
Spinal Flu
Spinal Fluid

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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