Neuronal nuclear type 1 Ab [Titer] in Cerebral spinal fluid 53711-8
LOINC Code
| LOINC code | 53711-8 | ||
|---|---|---|---|
| name | Neuronal nuclear type 1 Ab [Titer] in Cerebral spinal fluid | ||
| description | Anti-Neuronal Nuclear Antibody Type 1 Cerebrospinal fluid (CSF) titer. This antibody recognizes a 35-40 kD component found in neuronal cell nuclei. ANNA-1 antibody is found almost exclusively in patients with a history of tobacco use or passive exposure. Women are affected twice as often as men. Cancer has been found in more than 90% of seropositive patients. Small cell lung carcinoma (SCLC) has been found in 80% of patients. A second malignant neoplasm is found in 13% of patients positive for ANNA-1 who have SCLC. The most common clinical presentation of patients positive for ANNA-1 is peripheral neuropathy, but they can exhibit any element of encephalomyeloradiculopathy. About 10% of patients present with gastroparesis or intestinal obstruction. ANNA-1 has also been detected in children with intestinal dysmotility, cerbellar ataxia, and brainstem encephalitis with and without neuroblastoma. It is detected in 5 to 10% of patients with SCLC who do not have a paraneoplastic syndrome. Paraneoplastic syndromes are autoantibody-mediated neurologic disorders associated with underlying tumors. These syndromes arise when systemic tumors express antigens normally found only in neural tissue. Serum is the preferred specimen. CSF results are sometimes positive when serum results are negative. If a lumbar puncture is going to be performed as part of the diagnostic workup, CSF testing is recommended to improve the detection rate. Information from http://www.clinlabnavigator.com accessed 2008 15 02. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Neuronal nuclear type 1 Ab | ||
| property | Titr = Dilution Factor (Titer) | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | CSF = Cerebral spinal fluid | ||
| scale | SemiQn | ||
| method | |||
Additional Names | |||
| short name | Hu1 Ab Titr CSF | ||
Basic Attributes | |||
| class | SERO | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
| example UCUM units | {titer} The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | ||
| example unit | titer | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
Member of these Groups | |||
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History/Usage | |||
| test rank | 14753 of 2000 most commonly performed tests by labs in USA | ||
| first released | |||
| last updated | 2.75 | ||
| last change type | MAJ - change to name field other than Component; | ||
Related Names | |||
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