t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 fusion transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method   72212-4

LOINC Code


LOINC code72212-4
namet(15;17)(q24.1;q21.1)(PML,RARA) bcr1 fusion transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method
descriptionA balanced reciprocal translocation involving chromosomes 15 and 17, (15;17)(q22;q21), results in a fused transcript between PML and RARA genes. This gene fusion produces the PML-RARA fusion protein, a transcriptional repressor, which causes acute promyelocytic Leukemia (APL). Depending on the breakpoint within the PML gene, various fusion transcripts will be generated: long (L or bcr1), variant (V or bcr2), and short (S or bcr3). Techniques like real-time PCR are used to detect the PML-RARA fused transcripts and breakpoints. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.
statusACTIVE

Fully-Specified Name

componentt(15;17)(q24.1;q21.1)(PML,RARA) bcr1 fusion transcript/control transcript
propertyNRto  =  Number Ratio
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemBone mar  =  Marrow (bone)
scaleQn  =  Quantitative:  The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256
methodMolgen  =  Molecular Genetics:  General class of methods used to detect genetic attributes on a molecular basis including RFL, PCR and other methods.

Additional Names

short namet(15;17) BCR1/control Mar

Basic Attributes

classMOLPATH.TRNLOC
type1  Laboratory
order vs. observationBoth
example UCUM units%
The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org)
example unit%

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

History/Usage

first released
last updated2.42
last change typeMIN  - change to field other than name

Related Names

ABL
ABL1
ABL1 transcript
Acute promyelocytic leukemia
APL
BM
BON
Bone marrow
breakpoint cluster region 1
control gene
DNA
gene fusion
gene translocation
Genetics
Heredity
Heritable
Inherited
long form
MAR
Marrow (bone)
minimal angle of resolution
Minimum angle of resolution
Molecular genetics
Molecular pathology
MOLPATH
MOLPATH.TRANSLOCATION
Myelogenous
MYL
NR1B1
Number ratio
PCR
PML-1
PML-2
PML-3
PML-3B
PML-X
Point in time
Promyelocytic leukemia
QNT
Quan
Quant
Quantitative
Random
RAR alpha form
RARalpha
Retinoic acid receptor alpha
RNA
T prime
t(15,17) (PML,RARA) gene translocation
t(15,17)(PML,RARA) gene translocation breakpoint cluster region 1
t(15,17)(q22,q11.2-q12)
t(15
17) BCR1
t(15
17)(PML,RARA)
translocation

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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