t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method   72312-2

LOINC Code


LOINC code72312-2
namet(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
descriptionA translocation involving chromosomes 1 and 19, t(1;19)(q23;p13), results in a fused transcript between TCF3 (formerly E2A) and PBX1 (formerly prl) genes. The TCF3-PBX1 fusion gene is found in approximately 3% of childhood and adult precursor-B acute lymphoblastic leukemia (ALL). This code is based on, but not limited to, Ispogen's E2A-PBX1 FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific TCF3(E2A)-PBX1 fusion gene transcripts relative to a control gene transcript (e.g. ABL1). From the manufacturer's website (2012), "Quantification of E2A-PBX1 fusion gene transcripts has been standardized in the EAC (Europe Against Cancer) program [Gabert J et al. Leukemia. 2003, Beillard E et al. Leukemia. 2003], and IPSOGEN FusionQuant® kits use this validated technology to calibrate and normalize RQ-PCR results."
statusACTIVE

Fully-Specified Name

componentt(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript
propertyNRto  =  Number Ratio
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemBld/Tiss
    Bld  =  Whole blood
    Tiss  =  Tissue, unspecified
scaleQn  =  Quantitative:  The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256
methodMolgen  =  Molecular Genetics:  General class of methods used to detect genetic attributes on a molecular basis including RFL, PCR and other methods.

Additional Names

short namet(1;19)(PBX1,TCF3)/control Bld/T

Basic Attributes

classMOLPATH.TRNLOC
type1  Laboratory
order vs. observationBoth
example UCUM units%
The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org)
example unit%

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

Member of these Panels

72104-3Acute and chronic leukemia fusion transcript per control transcript panel - Blood or Tissue by Molecular genetics method

History/Usage

first released
last updated2.42
last change typeMIN  - change to field other than name

Related Names

ABL
ABL1
ABL1 transcript
Acute lymphoblastic leukaemia
Acute lymphoblastic leukemia
Acute myeloid leukemia
ALL
AML
Blood
control gene
DNA
E2A Immunoglobulin enhancer binding factors E12/E47
gene fusion
gene translocation
Genetics
Heredity
Heritable
i
Immunoglobulin transcription factor 1
Inherited
ITF1
Molecular genetics
Molecular pathology
MOLPATH
MOLPATH.TRANSLOCATION
Non-Hodgkin lymphoma
Number ratio
PBXP1
PCR
Point in time
Pre-B cell leukemia transcription factor-1
QNT
Quan
Quant
Quantitative
Random
RNA
T prime
t(1
19)(PBX1,TCF3)
Tissue
Tissue, unspecified
Transcription factor 3
translocation
WB
Whole blood
Whole blood or Tissue

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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