CYP2D6 gene and CYP2C19 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method   72886-5

LOINC Code


LOINC code72886-5
nameCYP2D6 gene and CYP2C19 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method
descriptionCYP2D6 and CYP2C19 cytochrome P450 genes play a major role in the metabolism of many widely prescribed drugs, including anti-depressants, anti-psychotics, anti-epileptics, proton pump inhibitors, and beta-blockers. The CYP2D6 gene has at least 70 allelic variants resulting in four phenotypic types: poor metabolizers with gene inactivation of both alleles, intermediate metabolizers with one reduced activity allele and one null allele, extensive metabolizers with at least one functional allele, and ultra-rapid metabolizers with excess enzymatic activity due to multiple copies of functional alleles from gene duplication. The CYP2C19 gene has two major variant alleles that result in enzyme deficiency. This panel term is created for, but not limited to, Roche Diagnostics' AmpliChip CYP450 assay, which detects 29 polymorphisms in the 2D6 and 2 polymorphisms in the 2C19 gene, as well as gene duplications and deletions.
statusACTIVE

Fully-Specified Name

componentCYP2D6 gene & CYP2C19 gene targeted mutation analysis panel
property-
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemBld/Tiss
    Bld  =  Whole blood
    Tiss  =  Tissue, unspecified
scale-
methodMolgen  =  Molecular Genetics:  General class of methods used to detect genetic attributes on a molecular basis including RFL, PCR and other methods.

Additional Names

short nameCYP2D6+CYP2C19 pnl Bld/T

Basic Attributes

classPANEL.MOLPATH.PHARMG
type1  Laboratory
order vs. observationOrder

Panel Components

40425-1CYP2D6 gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
79715-9CYP2D6 gene product metabolic activity interpretation in Blood or Tissue Qualitative by Molecular genetics method
57132-3CYP2C19 gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
79714-2CYP2C19 gene product metabolic activity interpretation in Blood or Tissue Qualitative by Molecular genetics method

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

History/Usage

first released
last updated2.67
last change typePANEL  - addition or removal of child elements or change in the conditionality of child elements in the panel or in sub-panels contained by the panel.
change reasonRelease 2.67: CLASS: Updated to PANEL.MOLPATH.PHARMG, the more representative LOINC Class for this concept.; SYSTEM: Updated System from "Bld/Tiss/Sal" to "Bld/Tiss" since this System in LOINC encompasses all specimens used for germline nucleic acid testing, including blood, tissue and cells contained in swabs as well as fluids such as saliva.; Previous Releases: Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.

Related Names

Blood
CPCJ
CPD6
CYP2C
CYP2D
CYP2D@
CYP2D6+CYP2C19
CYP2D6+CYP2C19 pnl
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIIC17
CYPIIC19
CYPIID6
Cytochrome p450
cytochrome P-450 II C
cytochrome P450, family 2, subfamily C, polypeptide 19
cytochrome P450, family 2, subfamily D, polypeptide 6
Debrisoquine hydroxylation gene
HGNC:2629
Molecular genetics
Molecular pathology
MOLPATH
MOLPATH.PHARMG
Mut
Mutations
P450C2C
P450C2D
P450DB1
P450-DB1
P450IIC19
Pan
Panel.molpath
Panel.molpath.pharmg
Panl
PCR
Pnl
Point in time
Random
Tissue
Tissue, unspecified
WB
Whole blood
Whole blood or Tissue

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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