MAML2 11q21 gene rearrangements in Tissue by FISH 74034-0
LOINC Code
| LOINC code | 74034-0 | ||
|---|---|---|---|
| name | MAML2 11q21 gene rearrangements in Tissue by FISH | ||
| description | Rearrangements within the MAML2 gene located on chromosome 11q21 are detected in tissue (e.g. salivary gland tumors) by in-situ hybridization (e.g. FISH) methods. Presence of split signals indicate gene rearrangement. MAML2 rearrangements must be present in greater than or equal to 10% of lesional cells in order to be considered positive. The submitter's lab for this term report results (e.g. percent of lesional cells, ISCN nomenclature, and qualification of a positive result) as descriptive text. For example, a narrative result may state, "50% of lesional cells contain MAML2 rearrangement, nuc ish(MAML2x2)(5MAML2 sep 3MAML2x1)[100/200]. MAML2 rearrangement must be present in greater than or equal to 10% of lesional cells in order to be considered positive." Results are used to diagnose Mucoepidermoid carcinoma (MEC). Other carcinomas, such as salivary duct carcinoma, adenosquamous carcinoma, acinic cell carcinoma, and Warthin tumor are negative for the MAML2 rearrangements. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | MAML2 11q21 gene rearrangements | ||
| property | Find = Finding | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Tiss = Tissue, unspecified | ||
| scale | Doc = Document: A document that could be in many formats (XML, narrative, etc.) | ||
| method | FISH | ||
Additional Names | |||
| short name | MAML2 11q21 Tiss FISH | ||
Basic Attributes | |||
| class | MOLPATH.REARRANGE | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.66 | ||
| last change type | MAJ - change to name field other than Component; | ||
| change reason | Based on LOINC Committee review (June 2019), updated the Property from "Prid" to "Find" and Scale from "Nar" to "Doc" to align with the current LOINC model for naming collections of information reported in narrative and/or structured formats. | ||
Related Names | |||
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