ERBB2 gene copy number/nucleus in Tissue by FISH   74860-8

LOINC Code


LOINC code74860-8
nameERBB2 gene copy number/nucleus in Tissue by FISH
descriptionThe average number of fluorescent signals targeting the ERBB2 gene (HER2 locus) in nuclei are determined in order to calculate the average ratio of ERBB2 gene to Chromosome 17 copy number [LOINC: 49683-6]. This term is based on, but not limited in use to, the PathVysion HER-2 DNA Probe Kit, which detects amplification of the ERBB2 gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens. The kit contains two probes: one specific to the HER-2/neu gene locus (ERBB2 gene, 17q11.2-q12) and another targeting the alpha satellite DNA sequence at the centromeric region of chromosome 17 (17p11.1-q11.1), called CEP17 (Chromosome Enumeration Probe 17). The average number of HER2 signals along with CEP17 signals [LOINC: 74861-6] are determined by microscopic examination within the same set of nuclei. The specimen is positive for ERBB2 gene amplification if the mean ratio of HER2 to CEP17 signals per nucleus is greater than or equal to 2.00.
statusACTIVE

Fully-Specified Name

componentERBB2 gene copy number/nucleus
propertyEntNum  =  Entitic Number
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemTiss  =  Tissue, unspecified
scaleQn  =  Quantitative:  The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256
methodFISH

Additional Names

short nameERBB2 copy num/nucleus EntNum Tiss FISH

Basic Attributes

classMOLPATH
type1  Laboratory
order vs. observationObservation
example UCUM units{#}
The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org)
example unit#

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

Member of these Panels

85904-1Cancer pathology panel - Breast cancer specimen by CAP cancer protocols
74885-5ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH

History/Usage

test rank9860 of 2000 most commonly performed tests by labs in USA
first released
last updated2.73
last change typeMIN  - change to field other than name
change reasonRelease 2.70: COMPONENT: Corrected the gene name based on the LOINC model to use the approved HGNC name for the gene that encodes the HER2 receptor.; Previous Releases: Updated "signals" in Component to "copy number" to align with current nomenclature and similar terms

Related Names

breast cancer
CD340
c-erb B2
Entitic
Entitic number
ErbB-2
ERBB2 copy num
erb-b2 receptor tyrosine kinase 2
Fluorescent in situ hybridization
Genetics
HER2
HER-2
HER2/neu
HER-2/neu
Heredity
Heritable
Inherited
MLN 19
Molecular pathology
MOLPATH
NEU
NGL
No
Num
p185
Point in time
QNT
Quan
Quant
Quantitative
Random
Tissue
Tissue, unspecified
TKR1
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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