Hepatocyte growth factor receptor Ag [Presence] in Tissue by Immune stain   77173-3

LOINC Code


LOINC code77173-3
nameHepatocyte growth factor receptor Ag [Presence] in Tissue by Immune stain
descriptionThe stain is interpreted as positive if 50% or more of the tumor cells show moderate to strong (2+, 3+) membranous staining, indicating MET amplification. MET amplification (positive) has been seen in approximately 22% of non-small-cell lung cases with acquired resistance to anti-EGFR inhibitors. Recent Phase II clinical trails (OAM4558g) results were released at ASCO in 2011 showed that patients who were c-MET positive (2+ or 3+) lived twice as long without disease progression (PFS) when they received MetMAb therapy in combination with erlotinib versus receiving erlotinib alone.
statusACTIVE

Fully-Specified Name

componentHepatocyte growth factor receptor Ag
propertyPrThr  =  Present or threshold:  The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold.
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemTiss  =  Tissue, unspecified
scaleOrd  =  Ordinal:  Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive.
methodImmune stain

Additional Names

short nameHGFR Ag Tiss Ql ImStn

Basic Attributes

classPATH
type1  Laboratory
order vs. observationBoth

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

History/Usage

test rank18014 of 2000 most commonly performed tests by labs in USA
first released
last updated2.73
last change typeMIN  - change to field other than name
change reasonThe PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Related Names

Antigen
Antigens
c-Met
Fac
Fact
Hepatopoietin A
HGF
HGFR
IHC
Imm
Immunohistochemical stain
Immunostain
ImStn
Imun
Imune
mesenchymal-epithelial transition
MET
Ordinal
PATHOLOGY
Point in time
PR
QL
Qual
Qualitative
Random
Rec
Recept
Receptors
Recp
Recptr
Scatter factor
Scatter Factor Receptor
Screen
SFR
St
Stains
Stn
Tissue
Tissue, unspecified
Transmembrane tyrosine kinase receptor
Tyrosine-protein kinase Met

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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